规格

价格

库存

数量

1 mg

¥ 2,000

5日内发货

5 mg

待询

5日内发货

10 mg

待询

5日内发货

1 mL x 10 mM (in DMSO)

待询

5日内发货

生物活性

产品描述	MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).
靶点活性	α5β1:12.2 nM (fibronectin-binding), αvβ6 integrin:0.7 nM (LAP-binding), αvβ5 integrin:0.1 nM (vitronectin-binding), αvβ3 integrin:80 nM, αvβ8 integrin:0.5 nM (LAP-binding), αvβ1 integrin:1.6 nM (fibronectin-binding)
体内活性	MK-0429 is safe and efficacious in obviously reducing melanoma metastasis in the lungs. MK-0429 (100 or 300 mg/kg, p.o., twice daily b.i.d., 2 weeks) decreases metastatic tumor colony formation and area in the lungs [1].
别名	L-000845704

化学信息

分子量	439.51
分子式	C₂₃H₂₉N₅O₄
CAS No.	227963-15-7
Smiles	COc1ccc(cn1)[C@H](CC(O)=O)N1CCN(CCCc2ccc3CCCNc3n2)C1=O
密度	1.36 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 250 mg/mL (568.82 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.51 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO