Fluspirilene (1.25, 2.5, and 5 μM) demonstrates the inhibition of proliferation of T98, U87, and all GSC lines, while Fluspirilene (2.5 and 5 μM) inhibits the proliferation of U251 and SNB19.[2]
Fluspirilene decreases the viability and suppresses the sphere-forming of glioma stem cell lines in a dose-dependent manner.[2]

Fluspirilene obviously prolongs the survival of the TGS04 mouse model. Mice treated with fluspirilene display a remarkable reduction in tumor size.[2]