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2-Aminoethanethiol

Name: 2-Aminoethanethiol
Brand: TargetMol
SKU: T1080
Price: 185 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.9%

货号 T1080Cas号 60-23-1

别名 巯基乙胺, β-Mercaptoethylamine, β-MEA, Cysteamine, 2-Mercaptoethylamine

2-Aminoethanethiol (Cysteamine) 是一种胱氨酸消耗剂。半胱胺的作用机制是胱氨酸二硫化物还原。

2-Aminoethanethiol

一键复制产品信息

很棒

纯度: 98.9%

货号 T1080 别名 巯基乙胺, β-Mercaptoethylamine, β-MEA, Cysteamine, 2-MercaptoethylamineCas号 60-23-1

2-Aminoethanethiol (Cysteamine) 是一种胱氨酸消耗剂。半胱胺的作用机制是胱氨酸二硫化物还原。

规格	价格	库存
100 mg	¥ 185	现货
500 mg	¥ 395	现货
1 g	¥ 568	现货
5 g	¥ 1,370	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: ≥95%

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资源下载:

COA HNMR 产品操作手册

产品介绍

2-Aminoethanethiol AI Summary

2-Aminoethanethiol exhibits a wide range of bioactivities and effects. At 250 µM, it impacts intracellular GSH (Glutathione) content in human macrophage-derived monocytes, resulting in a GSH level of 200.0. It facilitates cysteamine excretion in urine and feces and has an LD50 of 450.0 mg/kg in mice. When administered intraperitoneally at 225 mg/kg, it improves survival rates post-irradiation. 2-Aminoethanethiol inhibits Plasmodium falciparum with an IC50 of 200,000.0 nM and shows antiviral activity against HIV-1 with EC50 values of 41,600.0 nM and 53,700.0 nM depending on the assay. It cleaves single-stranded PNA and PNA:DNA duplexes efficiently and inhibits lipid peroxidation in rat hepatic microsomal membrane lipids at a concentration of 1 µM, with a 37.0% inhibition rate. Toxicity studies in Fischer 344 rats show 80.0% mortality at 1.6 mmol/kg subcutaneously, along with gastrointestinal toxicity and body weight decrease. 2-Aminoethanethiol inhibits human OCT1 uptake in HEK293 cells and shows a variety of other bioactivities, including effects on mitochondrial dynamics, thyroid stimulating hormone receptor activation, and inhibition of various enzymes and receptors. It was evaluated for drug-induced liver injury using the DILIps training set, showing no hepatic side effects across multiple assays and moderate acute liver toxicity in clinical trials. It inhibits human BSEP with an IC50 of 331,000.0 nM and demonstrates anti-inflammatory activity in Balb/C mice by reducing carrageenan-induced hind paw edema by 15.0% at 0.15 mmol/kg. No significant inhibition of histone lysine methyltransferases G9a and GLP was observed within the studied concentration range. Furthermore, 2-Aminoethanethiol possesses antioxidant properties against various radicals and shows moderate antiviral activity against SARS-CoV-2. It also exhibits specific HDAC6 inhibitory activity depending on the peptide substrate used..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2-Aminoethanethiol (Cysteamine) is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
别名	巯基乙胺, β-Mercaptoethylamine, β-MEA, Cysteamine, 2-Mercaptoethylamine

化学信息

分子量	77.15
分子式	C₂H₇NS
CAS No.	60-23-1
Smiles	NCCS
密度	0.973 g/cm3

储存&溶解度

存储

store at low temperature,store under nitrogen | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 194.4 mM, Sonication is recommended.

H2O: 194.4 mM, Sonication is recommended.

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	12.9618 mL	64.8088 mL	129.6176 mL	648.0881 mL
5 mM	2.5924 mL	12.9618 mL	25.9235 mL	129.6176 mL
10 mM	1.2962 mL	6.4809 mL	12.9618 mL	64.8088 mL
20 mM	0.6481 mL	3.2404 mL	6.4809 mL	32.4044 mL
50 mM	0.2592 mL	1.2962 mL	2.5924 mL	12.9618 mL
100 mM	0.1296 mL	0.6481 mL	1.2962 mL	6.4809 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Somatostatin Receptor ReactiveOxygenSpecies Reactive Oxygen Species NPYR2 EndogenousMetabolite Endogenous Metabolite Cystine CysteineProtease Cysteine Protease b-Mercaptoethylamine b-MEA beta-Mercaptoethylamine beta-MEA Autophagy Apoptosis 2-Aminoethanethiol 2Aminoethanethiol 2 Aminoethanethiol

2-Aminoethanethiol

2-Aminoethanethiol