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Anti-GFR Alpha-1/GFRA1 Antibody (4D654)

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Anti-GFR Alpha-1/GFRA1 Antibody (4D654)
产品编号 TMAY-03157
别名 TRNR1, RETL1, RET1L, GFR-α-1, GFR-ALPHA-1, GFR α-1/GFRA1, GDNFRA, GDNFR, GDNF family receptor α1, GDNF family receptor alpha 1

Anti-GFR Alpha-1/GFRA1 Antibody (4D654) 是一种 Rabbit 抗体,靶向 GFR Alpha-1/GFRA1。Anti-GFR Alpha-1/GFRA1 Antibody (4D654) 可用于 ELISA,IHC-P。

Anti-GFR Alpha-1/GFRA1 Antibody (4D654)

Anti-GFR Alpha-1/GFRA1 Antibody (4D654)

Rating icon 还可以
Anti-GFR Alpha-1/GFRA1 Antibody (4D654)
产品编号 TMAY-03157 别名 TRNR1, RETL1, RET1L, GFR-α-1, GFR-ALPHA-1, GFR α-1/GFRA1, GDNFRA, GDNFR, GDNF family receptor α1, GDNF family receptor alpha 1

Anti-GFR Alpha-1/GFRA1 Antibody (4D654) 是一种 Rabbit 抗体,靶向 GFR Alpha-1/GFRA1。Anti-GFR Alpha-1/GFRA1 Antibody (4D654) 可用于 ELISA,IHC-P。

规格价格库存数量
20 μL
¥ 780
5日内发货
100 μL
¥ 2,289
5日内发货
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实验操作小课堂
常见问题解答
化合物带有盐酸盐离子、硫酸盐离子等是否和其本身有什么区别?盐形式和游离态有什么区别?
盐和非盐形式化合物的活性分子是一样的,在生物实验中起到的效果也一致,活性和使用方法都是一样的。只是由于呈盐不同,物理性质比如溶解度会有差异。建议您根据溶解、实验需求进行选择。
如何选择某个靶点的特异性或总的抑制剂?特异性和非特异性的区别是什么?
抑制剂按照特异性分为广谱 pan 和特异性 selective 两种。Pan 为某个靶点总的抑制剂,对所有亚型或整个家族的成员都有抑制作用。Selective 抑制剂针对某个蛋白激酶的某个亚型或家族中某个成员抑制率特别高或有特异性抑制作用。 一般评价一个抑制剂的抑制效率主要看 IC50 值,IC50 值越低,说明抑制剂效率越高。建议您根据以上几个特征进行综合选择,也可联系技术帮您推荐相关抑制剂。
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产品介绍

生物活性
产品描述
Anti-GFR Alpha-1/GFRA1 Antibody (4D654) is a Rabbit antibody targeting GFR Alpha-1/GFRA1. Anti-GFR Alpha-1/GFRA1 Antibody (4D654) can be used in ELISA,IHC-P.
别名TRNR1, RETL1, RET1L, GFR-α-1, GFR-ALPHA-1, GFR α-1/GFRA1, GDNFRA, GDNFR, GDNF family receptor α1, GDNF family receptor alpha 1
Ig Type
Rabbit IgG
克隆号
4D654
交叉反应
Mouse
验证活性
1. Immunochemical staining of mouse GFRa1 in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
2. Immunochemical staining of mouse GFRa1 in mouse brain with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
应用
推荐剂量
ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse GFRA1 (rM GFRA1; TMPY-01088; AAB86600.1; Met 1-Ser 425).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 1 (GFRA1) is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA1 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. GDNF, a distantly related member of the transforming growth factor-β (TGF-â) superfamily, and its receptor components: GFRA1, Ret and neural cell adhesion molecule (NCAM) have been recently reported to be expressed in the testis and to be involved in the proliferation regulation of immature Sertoli cells.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Mouse GFRA1 protein (TMPY-01088)
抗原种属
Mouse
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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4个月前
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