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顶部生物活性储存和溶解信息计算器

Anti-Angiopoietin-1 Antibody (5C751)

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产品编号 TMAY-02623

Anti-Angiopoietin-1 Antibody (5C751) 是一种 Mouse 抗体，靶向 Angiopoietin-1。Anti-Angiopoietin-1 Antibody (5C751) 可用于 ELISA。

Anti-Angiopoietin-1 Antibody (5C751)

Anti-Angiopoietin-1 Antibody (5C751)

一键复制产品信息
Rating icon 还可以
产品编号 TMAY-02623

Anti-Angiopoietin-1 Antibody (5C751) 是一种 Mouse 抗体，靶向 Angiopoietin-1。Anti-Angiopoietin-1 Antibody (5C751) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 1,689
5日内发货
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产品介绍

生物活性
产品描述
Anti-Angiopoietin-1 Antibody (5C751) is a Mouse antibody targeting Angiopoietin-1. Anti-Angiopoietin-1 Antibody (5C751) can be used in ELISA.
Ig Type
Mouse IgG2b
克隆号
5C751
交叉反应
Human
特异性
Human Angiopoietin-1/ANGPT1
应用ELISA
推荐剂量
ELISA: 1:1000-1:2000
抗体种类
Monoclonal
宿主来源Mouse
构建方式This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Angiopoietin-1 (rh Angiopoietin-1; TMPY-05435; NP_001137.2; Met1-Leu261 and Arg277-Phe498). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. A role for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure. By linking ANGPT1 with PCG, these results highlight the importance of ANGPT/TEK signaling in glaucoma pathogenesis and identify a candidate target for therapeutic development.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human Angiopoietin-1 Protein (TMPY-05435)
抗原种属
Human
研究领域
Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

Angpt1Angpt 1Angiopoietin-1Angiopoietin1ANG-1ANG1

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4个月前
5.0
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