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FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated

产品编号 TMPY-06665

FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 88.34 kDa and the accession number is NP_034358.2.

FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated

产品编号 TMPY-06665

规格	价格	库存
5 μg	¥ 1,350	6-8日内发货
10 μg	¥ 2,270	6-8日内发货
20 μg	¥ 3,820	5日内发货
50 μg	¥ 5,930	5日内发货
100 μg	¥ 9,870	5日内发货

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产品信息

生物活性	1. Immobilized Recombinant Human / Cynomolgus VEGF / VEGFA / VEGF165 Protein at 2μg/mL (100μL/well) can bind Recombinant Mouse FLT1 Protein (ECD, His & AVI Tag), Biotinylated , the EC50 is 7-20 ng/mL. 2. Immobilized Recombinant Human PLGF Protein (Fc Tag) at 2μg/mL (100μL/well) can bind Recombinant Mouse FLT1 Protein (ECD, His & AVI Tag), Biotinylated , the EC50 is 3-10 ng/mL.
产品描述	FLT1 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 88.34 kDa and the accession number is NP_034358.2.
种属	Mouse
表达系统	HEK293 Cells
标签	C-His-Avi
蛋白编号	NP_034358.2
别名	VEGFR-1,VEGFR1,sFlt1,fms-related tyrosine kinase 1,Flt-1,AI323757
蛋白构建	A DNA sequence encoding the Mouse FLT1 (NP_034358.2) (Met1-Glu759) was expressed with a C-terminal polyhistidine tag followed by an AVI tag. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. Predicted N terminal: Met 1
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	88.34 kDa (predicted); 112.08 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to theprotein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains sevenIg-like C2-type (immunoglobulin-like) domains and oneprotein kinase domain. VEGFR-1 / FLT1 is expressed mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR-1 / FLT1 is not expressed in tumor cell lines. VEGFR-1 / FLT1 is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis. EGF-induced angiogenesis requires inverse regulation of VEGFR-1 and VEGFR-2 in tumor-associated endothelial cells. VEGFR-1 / FLT1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy