规格

价格

库存

数量

1 mg

¥ 1,650

现货

5 mg

¥ 4,890

现货

10 mg

¥ 6,780

现货

生物活性

产品描述	Duramycin is a lantibiotic peptide antibiotic derived from Streptomyces cinnamoneus. It also functions as an ion channel modulator and has been investigated for cystic fibrosis (CF).
体外活性	Duramycin affects protein-lipid interactions, impairs protein translocation, induces aggregation of lipid vesicles, and inhibits ATP-dependent Ca2+ uptake by the sarcoplasmic reticulum.
体内活性	[68Ga]NODAGA-Duramycin PET/CT成功地用于在小鼠中高灵敏度地非侵入性检测化疗诱导的器官毒性。[68Ga]NODAGA-Duramycin作为正电子发射断层扫描(PET)细胞死亡示踪剂用于全身检测化疗诱导的器官毒性的评价。在静脉注射[68Ga]no daga-耐久霉素后2小时，分析未治疗和阿霉素、白消安和顺铂治疗的小鼠的器官摄取。
别名	兰考韦泰, Moli-1901, Moli1901, Moli 1901, Lancovutide

化学信息

分子量	2013.28
分子式	C₈₉H₁₂₅N₂₃O₂₅S₃
CAS No.	1391-36-2
Smiles	O=C(N)CCC1NC(=O)C(NC(=O)C(N)CSC(C)C2NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C3NC(=O)C(NC(=O)C(NC(=O)C4NC(=O)C(NC(=O)C5N(C(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CSC3)CSC4C)CNCCCCC(NC2=O)C(=O)O)CC=6C=CC=CC6)CCC5)CC=7C=CC=CC7)CC=8C=CC=CC8)C(C)C)C(O)C(=O)O)CC(=O)N)CCCCN
密度	1.0238 g/cm3 (Estimated)
Sequence	Cys-Lys-Gln-Cys-Cys-Ala-Phe-Gly-Pro-Phe-{Abu}-Phe-Val-Cys-Asp-Gly-Asn-{Abu}-Lys-NH2 (Disulfide bridge: Cys1-Abu18, Cys4-Cys14, Cys5-Abu11)
Sequence Short	CKQCCAFGPF-{Abu}-FVCDGN-{Abu}-K-NH2 (Disulfide bridge: Cys1-Abu18, Cys4-Cys14, Cys5-Abu11)

储存&溶解度

存储

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: < 1?mg/mL?(insoluble), Sonication is recommended.

0.1 M HCl: 10.00 mg/mL (4.97 mM), Sonication is recommended.

溶液配制表

0.1 M HCl

	1mg	5mg	10mg	50mg
1 mM	0.4967 mL	2.4835 mL	4.9670 mL	24.8351 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Duramycin