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Anti-IL-24 Antibody (1H832) 是一种 Rabbit 抗体,靶向 IL-24。Anti-IL-24 Antibody (1H832) 可用于 ELISA。
Anti-IL-24 Antibody (1H832) 是一种 Rabbit 抗体,靶向 IL-24。Anti-IL-24 Antibody (1H832) 可用于 ELISA。
产品描述 | Anti-IL-24 Antibody (1H832) is a Rabbit antibody targeting IL-24. Anti-IL-24 Antibody (1H832) can be used in ELISA. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 1H832 |
交叉反应 | Human |
应用 | ELISA |
推荐剂量 | ELISA: 1:5000-1:10000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-24/MDA-7 (rh IL-24/MDA-7; NP_001172085.1; Met1-Leu207). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Interleukin-24 (IL-24) also known as Melanoma differentiation-associated gene 7 protein (MDA-7) is a member of the IL10 family of cytokines. IL-24/MDA-7/IL24 can induce apoptosis selectively in various cancer cells. Overexpression of IL-24 leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Human IL-24/MDA-7/IL24 is secreted by activated peripheral blood mononuclear cells and is the ligand for two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. Northern blot analysis revealed IL-24/MDA-7/IL24 expression in human tissues associated with the immune system such as the spleen, thymus, peripheral blood leukocytes, and normal melanocytes. IL-24/MDA-7/IL24 binding to either its endogenous receptors on human keratinocytes or to ectopically expressed receptors on baby hamster kidney cells leads to activation of the signal transducers and activators of transcription. |
偶联 | Unconjugated |
免疫原 | Recombinant Human IL-24/MDA-7 Protein |
抗原种属 | Human |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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