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Anti-FGFR2 Antibody (8U49)
还可以产品编号 TMAY-01229
Anti-FGFR2 Antibody (8U49) 是一种 Rabbit 抗体，靶向 FGFR2。Anti-FGFR2 Antibody (8U49) 可用于 ELISA。
Anti-FGFR2 Antibody (8U49)
Anti-FGFR2 Antibody (8U49)
还可以产品编号 TMAY-01229
Anti-FGFR2 Antibody (8U49) 是一种 Rabbit 抗体，靶向 FGFR2。Anti-FGFR2 Antibody (8U49) 可用于 ELISA。
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偶联与修饰
抗原信息
| 产品描述 | Anti-FGFR2 Antibody (8U49) is a Rabbit antibody targeting FGFR2. Anti-FGFR2 Antibody (8U49) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8U49 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human FGFR2 extracellular domain (rh FGFR2; TMPY-01228; NP_000132.3; Met 1-Glu 377). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human FGFR2 protein (TMPY-01228) |
| 抗原种属 | Human |
| 研究领域 | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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