规格

价格

库存

数量

1 mg

¥ 1,160

现货

5 mg

¥ 2,570

现货

10 mg

¥ 3,970

现货

25 mg

¥ 6,380

现货

50 mg

¥ 8,590

现货

100 mg

¥ 11,600

现货

1 mL x 10 mM (in DMSO)

¥ 2,820

现货

生物活性

产品描述	Nav1.1 activator 1 (compound 4) is an effective Nav1.1 agonist with blood-brain barrier permeability, exhibiting significant selectivity for Nav1.2, Nav1.5, and Nav1.6. It increases the decay time constant of Nav1.1 at 0.03 μM current and can be used for studying central nervous system disorders.
体内活性	方法：在药代动力学分析中，对小鼠30 mg/kg的Nav1.1 activator 1(单次给药;腹腔注射)，1小时后测量暴露量。结果：Nav1.1 activator 1可导致足够的脑暴露(193 ng/g)，能够穿透血脑屏障（BBB）。
别名	Nav1.1 激活剂 1

化学信息

分子量	440.46
分子式	C₂₄H₂₃F₃N₄O
CAS No.	2332897-85-3
Smiles	C(NC=1C=CC(C(C)C)=NC1)(=O)C=2C(=CC=NC2N3C[C@@H](F)CC3)C4=C(F)C=CC(F)=C4
密度	1.32 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 200 mg/mL (454.07 mM), Sonication is recommended.

溶液配制表

DMSO