规格

价格

库存

数量

2 mg

¥ 740

5日内发货

5 mg

¥ 1,230

5日内发货

10 mg

¥ 1,980

5日内发货

25 mg

¥ 4,280

5日内发货

1 mL x 10 mM (in DMSO)

¥ 1,370

5日内发货

生物活性

产品描述	Devazepide is a competitive, selective, orally available non-peptide CCK1 (cholecystokinin 1) receptor antagonist that inhibits bladder cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest.
靶点活性	CCK receptor (rat pancreas):45 pM, CCK receptor (guinea pig brain):245 nM, CCK receptor (bovine gallbladder):81 pM
体内活性	Devazepide经口灌胃给予（4 mg/kg，每日两次）可显著加快胆固醇结晶形成、晶体生长直至发展为微结石，并促进小鼠胆结石的发生[2]。腹腔注射Devazepide（0.1–1 mg/kg）对小鼠的基础自发活动与雨蛙素、阿扑吗啡所致的运动功能减退呈现相反的调节作用[3]。
别名	地伐西匹, MK-329, MK329, L-364,718, L364,718

化学信息

分子量	408.45
分子式	C₂₅H₂₀N₄O₂
CAS No.	103420-77-5
Smiles	N(C(=O)C1=CC=2C(N1)=CC=CC2)[C@H]3N=C(C=4C(N(C)C3=O)=CC=CC4)C5=CC=CC=C5
密度	1.31 g/cm3 (Predicted)
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 160 mg/mL (391.72 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4483 mL	12.2414 mL	24.4828 mL	122.4140 mL
5 mM	0.4897 mL	2.4483 mL	4.8966 mL	24.4828 mL
10 mM	0.2448 mL	1.2241 mL	2.4483 mL	12.2414 mL
20 mM	0.1224 mL	0.6121 mL	1.2241 mL	6.1207 mL
50 mM	0.0490 mL	0.2448 mL	0.4897 mL	2.4483 mL
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2241 mL