Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) 是特异性的MT1和MT2受体激动剂,对 CHO-hMT1的Ki 值为0.1 nM,对HEK-hMT1的Ki 值为0.06 nM,对CHO-hMT2的Ki 值为0.12 nM,对HEK-hMT2 的Ki 值为0.27 nM。Agomelatine hydrochloride 是选择性的5-羟色胺2C(5-HT2C)受体拮抗剂,对天然 (猪) 和克隆的人 5-HT2C 受体的pKi 值分别为 6.4 和 6.2。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 172 | 现货 | ||
5 mg | ¥ 378 | 现货 | ||
10 mg | ¥ 592 | 现货 | ||
25 mg | ¥ 1,090 | 现货 | ||
50 mg | ¥ 1,880 | 现货 | ||
100 mg | ¥ 2,880 | 现货 | ||
200 mg | ¥ 4,180 | 现货 | ||
500 mg | ¥ 6,530 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 418 | 现货 |
产品描述 | Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for HEK-hMT1, 0.12 nM for CHO-hMT2, and 0.27 nM for HEK-hMT2, respectively [1]. Agomelatine hydrochloride is a selective antagonist of a 5-HT2C receptor with pKis of 6.4 and 6.2 for native (porcine) and cloned, human 5-HT2C receptors, respectively [2]. |
体外活性 | Agomelatine (S 20098) acts as a full agonist of MT1 and MT2 receptors with EC50s of 1.6±0.4, 0.10±0.04 nM for CHO hMT1 CHO-hMT2 (hΜΤ1 and hΜΤ2 receptors expressed in CHO or HEK cell membranes)[1]. Agomelatine (S20098) also interacts with h5-HT2B receptors (6.6), whereas it shows low affinity at native (rat)/cloned, human 5-HT2A (<5.0/5.3) and 5-HT1A (<5.0/5.2) receptors, and negligible (<5.0) affinity for other 5-HT receptors[2]. |
体内活性 | Agomelatine (25, 50, or 75 mg/kg; i.p.) has antioxidant activity in Strychnine (75 mg/kg, i.p.) or Pilocarpine (400 mg/kg, i.p.) induced seizure models in mice. Agomelatine dose not have any antioxidant effects on parameters of oxidative stress produced by Pentylenetetrazole (PTZ) or Picrotoxin (PTX) induced seizure models when compared to controls[3]. |
别名 | S-20098 hydrochloride |
分子量 | 279.76 |
分子式 | C15H18ClNO2 |
CAS No. | 1176316-99-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 0.1 mg/mL (insoluble)
DMSO: 90mg/mL (321.7mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.5745 mL | 17.8725 mL | 35.7449 mL | 89.3623 mL |
5 mM | 0.7149 mL | 3.5745 mL | 7.149 mL | 17.8725 mL | |
10 mM | 0.3574 mL | 1.7872 mL | 3.5745 mL | 8.9362 mL | |
20 mM | 0.1787 mL | 0.8936 mL | 1.7872 mL | 4.4681 mL | |
50 mM | 0.0715 mL | 0.3574 mL | 0.7149 mL | 1.7872 mL | |
100 mM | 0.0357 mL | 0.1787 mL | 0.3574 mL | 0.8936 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Agomelatine hydrochloride 1176316-99-6 Neuroscience MT Receptor S-20098 Hydrochloride Agomelatine Hydrochloride S 20098 Hydrochloride S20098 Hydrochloride S-20098 hydrochloride Inhibitor inhibitor inhibit