keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TfR-T12 is a transferrin receptor (TfR) binding peptide that can penetrate the blood-brain barrier (BBB), exhibiting a high binding affinity within the nanomolar (nM) range. 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 TfR-T12 acetate 的水溶性和稳定性通常比游离态更好。
产品描述 | TfR-T12 is a transferrin receptor (TfR) binding peptide that can penetrate the blood-brain barrier (BBB), exhibiting a high binding affinity within the nanomolar (nM) range. |
体外活性 | TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells[1]. TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[2]. |
别名 | TfR-T12 |
分子量 | 1490.75 |
分子式 | C71H99N19O15S |
CAS No. | 344618-30-0 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TfR-T12 344618-30-0 TfR-T-12 TfR T12 TfRT12 Inhibitor inhibitor inhibit