YNT-185 dihydrochloride

Name: YNT-185 dihydrochloride
Brand: TargetMol
SKU: T37112
Rating: 4.5 (1 reviews)

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货号 T37112Cas号 1804978-82-2

Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

YNT-185 dihydrochloride

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货号 T37112Cas号 1804978-82-2

规格	价格	库存
2 mg	¥ 867	5日内发货
5 mg	¥ 1,490	5日内发货
10 mg	¥ 2,740	5日内发货

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产品介绍

生物活性

产品描述	Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.
靶点活性	OX1 receptor:2.75 μM (EC50), OX2 receptor:0.028 μM (EC50)

化学信息

分子量	688.67
分子式	C₃₃H₃₉Cl₂N₅O₅S
CAS No.	1804978-82-2
Smiles	Cl.Cl.COc1ccc(cc1S(=O)(=O)Nc1cccc(NCCNC(=O)c2ccccc2N(C)C)c1)-c1cccc(c1)C(=O)N(C)C

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
溶解度信息	DMSO: Soluble