Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2].
产品描述 | T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2]. |
体外活性 | PPI-0903M is very active against S. aureus (MIC50=0.25 μg/mL), including methicillin-resistant (MRSA) strains (MIC50=1 μg/mL)[1].PPI-0903M is active against hetero-vancomycin-intermediate S. aureus (100 strains), with MIC50s ranging from 0.25 to 4 μg/mL[1]. |
体内活性 | AK-599 (20 mg/kg; s.c. three times a day for 2 days) decreases the bacterial cell counts in lungs more than 99.9% in a mouse pneumonia model caused by MRSA[2]. |
分子量 | 604.69 |
分子式 | C22H20N8O5S4 |
CAS No. | 189345-04-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (165.37 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6537 mL | 8.2687 mL | 16.5374 mL | 41.3435 mL |
5 mM | 0.3307 mL | 1.6537 mL | 3.3075 mL | 8.2687 mL | |
10 mM | 0.1654 mL | 0.8269 mL | 1.6537 mL | 4.1343 mL | |
20 mM | 0.0827 mL | 0.4134 mL | 0.8269 mL | 2.0672 mL | |
50 mM | 0.0331 mL | 0.1654 mL | 0.3307 mL | 0.8269 mL | |
100 mM | 0.0165 mL | 0.0827 mL | 0.1654 mL | 0.4134 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
T-91825 189345-04-8 T91825 T 91825 Inhibitor inhibitor inhibit