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CD40 Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-05425

别名: IGM, AI326936, TRAP, T-BAM, p50, IMD3, Tnfrsf5, HIGM1, GP39, Bp50, CD40 molecule, TNF receptor superfamily member 5

CD40 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is P27512-1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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CD40 Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,170		5日内发货
1 mg	￥ 20,800		5日内发货

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生物活性

技术参数

产品性质

参考文献

生物活性	Measured by its binding ability in a functional ELISA. Immobilized mCD40-Fc at 10 μg/mL (100 μL/well) can bind cynoCD40LG-Fc/Biotin .
产品描述	CD40 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is P27512-1.

种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P27512-1
别名	IGM, AI326936, TRAP, T-BAM, p50, IMD3, Tnfrsf5, HIGM1, GP39, Bp50, CD40 molecule, TNF receptor superfamily member 5
蛋白构建	The Mouse CD40 (NP_035741.2) (Met1-Arg193) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	46.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

参考文献

1. van Kooten C,et al.(2000). CD40-CD40 ligand. J Leukoc Biol. 67 (1): 2-17. 2. Bhushan A,et al.(2002). CD40:CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24 (3): 311-24. 3. Chatzigeorgiou A,et al.(2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-83. 4. Li R,et al.(2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-17. 5. Lievens D,et al.(2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

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Keywords

CD40 Protein, Mouse, Recombinant (hFc) HIGM 1 IMD-3 IGM AI326936 TRAP T-BAM p50 AI-326936 IMD3 GP-39 Tnfrsf5 HIGM-1 HIGM1 GP 39 GP39 Bp50 IMD 3 AI 326936 CD40 molecule, TNF receptor superfamily member 5 recombinant recombinant-proteins proteins protein

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