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DR6 Protein, Mouse, Recombinant (hFc & His)

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货号 TMPJ-00358

别名 Tumor necrosis factor receptor superfamily member 21, Tnfrsf21, DR6, Death receptor 6, CD358, BM-018

Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

DR6 Protein, Mouse, Recombinant (hFc & His)
其他形式的 “DR6 Protein, Mouse, Recombinant (hFc & His)”:
DR6 Protein, Cynomolgus, Recombinant (His)
DR6 Protein, Human, Recombinant (hFc)
DR6 Protein, Human, Recombinant
DR6 Protein, Human, Recombinant (His)
DR6 Protein, Mouse, Recombinant (His)
DR6 Protein, Rat, Recombinant (hFc)

DR6 Protein, Mouse, Recombinant (hFc & His)

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Rating icon 还可以
SPR兼容缓冲液
货号 TMPJ-00358 别名 Tumor necrosis factor receptor superfamily member 21, Tnfrsf21, DR6, Death receptor 6, CD358, BM-018

Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

规格价格库存数量
5 μg
¥ 456
6-8日内发货
10 μg
¥ 740
6-8日内发货
20 μg
¥ 1,120
5日内发货
50 μg
¥ 1,970
5日内发货
100 μg
¥ 3,380
5日内发货
200 μg
¥ 5,850
5日内发货
500 μg
¥ 12,100
5日内发货
1 mg
¥ 17,300
5日内发货
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产品介绍

生物活性
产品描述
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
生物活性
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
研究背景
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
种属
Mouse
表达系统
HEK293 Cells
标签C-hFc-6xHis
蛋白编号Q9EPU5
氨基酸序列Gln42-His349
蛋白构建Gln42-His349
蛋白纯度
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名Tumor necrosis factor receptor superfamily member 21, Tnfrsf21, DR6, Death receptor 6, CD358, BM-018
内毒素< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
化学信息
分子量75-120 KDa (reducing condition)
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
存储Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

计算器

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剂量转换

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技术支持

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关键词

DR-6DR 6CD-358CD 358BM018BM 018
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