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NNC 55-0396

Name: NNC 55-0396
Brand: TargetMol
SKU: T12238
Price: 487 CNY
Availability: InStock
Rating: 5 (10 reviews)

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货号 T12238Cas号 357400-13-6

别名 NNC 55-0396 dihydrochloride

NNC 55-0396 是一种高特异性的 T 型钙通道阻滞剂，IC50 为 6.8 μM。 NNC 55-0396 可用于预防人类卵巢癌细胞增殖的研究。

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NNC 55-0396

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货号 T12238 别名 NNC 55-0396 dihydrochlorideCas号 357400-13-6

NNC 55-0396 是一种高特异性的 T 型钙通道阻滞剂，IC50 为 6.8 μM。 NNC 55-0396 可用于预防人类卵巢癌细胞增殖的研究。

规格	价格	库存
1 mg	¥ 487	现货
5 mg	¥ 1,310	现货
10 mg	¥ 2,150	现货
25 mg	¥ 3,620	现货
50 mg	¥ 5,160	现货
100 mg	¥ 6,950	现货
200 mg	¥ 9,560	现货
1 mL x 10 mM (in DMSO)	¥ 1,630	现货

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产品介绍

NNC 55-0396 AI Summary

NNC 55-0396 exhibits a broad spectrum of bioactivities, including inhibitory effects on various enzymes and virus interactions. It is known to inhibit genomic imprint erasure, tau fibril formation, ROR gamma transcriptional activity, ALDH1A1, Bacillus subtilis Sfp PPTase, Menin-MLL interaction in MLL-related leukemias, Fructose-1,6-bisphosphate aldolase from Giardia Lamblia, N370S glucocerebrosidase, histone lysine methyltransferase G9a, 15-human lipoxygenase 2, human flap endonuclease 1 (FEN1), TGF-b, polymerase kappa, human tyrosyl-DNA phosphodiesterase 1 (TDP1), alpha-synuclein, Stage-Specific Inhibitors of Vaccinia Orthopoxvirus, and inhibiting the binding or entry into cells by Lassa Virus and Marburg Virus. In terms of calcium channel inhibition, NNC 55-0396 inhibits Cav2.2 in human SH-SY5Y cells with an IC50 of 7000.0 nM and Cav3.2-alpha1 in HEK293T cells with an IC50 of 2000.0 nM. The compound also displays antiviral properties. Specifically, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 μM concentration after 48 hours, with an 11.35% inhibition rate. It has an IC50 value of 8210.0 nM against SARS-CoV-2 in VERO-E6 cells and an inhibition rate of -1.739% at 20 μM concentration against the SARS-CoV-2 3CL-Pro protease. The high selectivity index of 0.99 against SARS-CoV-2 highlights its specificity with low toxicity in VERO-E6 cells. Finally, NNC 55-0396 demonstrates inhibitory activity against human HDAC6 enzyme, with inhibition percentages of 15.09% using a commercial peptide substrate and -3.03% with a custom peptide substrate, suggesting variability depending on the substrate used..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NNC 55-0396 is a highly selective blocker of T-type calcium channel with IC50 of 6.8 μM. NNC 55-0396 can be used in studies about preventing human ovarian cancer cell proliferation.
别名	NNC 55-0396 dihydrochloride

化学信息

分子量	564.56
分子式	C₃₀H₄₀Cl₂FN₃O₂
CAS No.	357400-13-6
Smiles	Cl.Cl.CC(C)C1c2ccc(F)cc2CCC1(CCN(C)CCCc1nc2ccccc2[nH]1)OC(=O)C1CC1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 95 mg/mL (168.27 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.85 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7713 mL	8.8565 mL	17.7129 mL	88.5645 mL
5 mM	0.3543 mL	1.7713 mL	3.5426 mL	17.7129 mL
10 mM	0.1771 mL	0.8856 mL	1.7713 mL	8.8565 mL
20 mM	0.0886 mL	0.4428 mL	0.8856 mL	4.4282 mL
50 mM	0.0354 mL	0.1771 mL	0.3543 mL	1.7713 mL
100 mM	0.0177 mL	0.0886 mL	0.1771 mL	0.8856 mL