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NNC 55-0396

Name: NNC 55-0396
Brand: TargetMol
SKU: T12238
Price: 487 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: NNC 55-0396 dihydrochloride

货号 T12238Cas号 357400-13-6 一键复制产品信息纯度: 99.00%

很棒

NNC 55-0396 是一种高特异性的 T 型钙通道阻滞剂，IC50 为 6.8 μM。 NNC 55-0396 可用于预防人类卵巢癌细胞增殖的研究。

NNC 55-0396

一键复制产品信息

很棒

纯度: 99.00%

货号 T12238Cas号 357400-13-6

别名 NNC 55-0396 dihydrochloride

NNC 55-0396 是一种高特异性的 T 型钙通道阻滞剂，IC50 为 6.8 μM。 NNC 55-0396 可用于预防人类卵巢癌细胞增殖的研究。

规格	价格	库存
1 mg	¥ 487	现货
5 mg	¥ 1,310	现货
10 mg	¥ 2,150	现货
25 mg	¥ 3,620	现货
50 mg	¥ 5,160	现货
100 mg	¥ 6,950	现货
200 mg	¥ 9,560	现货
1 mL x 10 mM (in DMSO)	¥ 1,630	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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常见问题解答

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纯度: 99.00%

颜色: 白色

性状: Solid

资源下载: COA LCMS HNMR产品操作手册

产品介绍

NNC 55-0396 AI Summary

NNC 55-0396 exhibits a broad spectrum of bioactivities, including inhibitory effects on various enzymes and virus interactions. It is known to inhibit genomic imprint erasure, tau fibril formation, ROR gamma transcriptional activity, ALDH1A1, Bacillus subtilis Sfp PPTase, Menin-MLL interaction in MLL-related leukemias, Fructose-1,6-bisphosphate aldolase from Giardia Lamblia, N370S glucocerebrosidase, histone lysine methyltransferase G9a, 15-human lipoxygenase 2, human flap endonuclease 1 (FEN1), TGF-b, polymerase kappa, human tyrosyl-DNA phosphodiesterase 1 (TDP1), alpha-synuclein, Stage-Specific Inhibitors of Vaccinia Orthopoxvirus, and inhibiting the binding or entry into cells by Lassa Virus and Marburg Virus. In terms of calcium channel inhibition, NNC 55-0396 inhibits Cav2.2 in human SH-SY5Y cells with an IC50 of 7000.0 nM and Cav3.2-alpha1 in HEK293T cells with an IC50 of 2000.0 nM. The compound also displays antiviral properties. Specifically, it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells at 10 μM concentration after 48 hours, with an 11.35% inhibition rate. It has an IC50 value of 8210.0 nM against SARS-CoV-2 in VERO-E6 cells and an inhibition rate of -1.739% at 20 μM concentration against the SARS-CoV-2 3CL-Pro protease. The high selectivity index of 0.99 against SARS-CoV-2 highlights its specificity with low toxicity in VERO-E6 cells. Finally, NNC 55-0396 demonstrates inhibitory activity against human HDAC6 enzyme, with inhibition percentages of 15.09% using a commercial peptide substrate and -3.03% with a custom peptide substrate, suggesting variability depending on the substrate used..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	NNC 55-0396 is a highly selective blocker of T-type calcium channel with IC50 of 6.8 μM. NNC 55-0396 can be used in studies about preventing human ovarian cancer cell proliferation.
别名	NNC 55-0396 dihydrochloride

化学信息

分子量	564.56
分子式	C₃₀H₄₀Cl₂FN₃O₂
CAS No.	357400-13-6
Smiles	Cl.Cl.CC(C)C1c2ccc(F)cc2CCC1(CCN(C)CCCc1nc2ccccc2[nH]1)OC(=O)C1CC1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 150 mg/mL (265.69 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.85 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7713 mL	8.8565 mL	17.7129 mL	88.5645 mL
5 mM	0.3543 mL	1.7713 mL	3.5426 mL	17.7129 mL
10 mM	0.1771 mL	0.8856 mL	1.7713 mL	8.8565 mL
20 mM	0.0886 mL	0.4428 mL	0.8856 mL	4.4282 mL
50 mM	0.0354 mL	0.1771 mL	0.3543 mL	1.7713 mL
100 mM	0.0177 mL	0.0886 mL	0.1771 mL	0.8856 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。