Name: Selgantolimod
Brand: TargetMol
SKU: T16870
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

2 mg

待询

5日内发货

25 mg

¥ 35,400

6-8周

50 mg

¥ 46,300

6-8周

100 mg

¥ 55,400

6-8周

1 mL x 10 mM (in DMSO)

¥ 21,500

5日内发货

生物活性

产品描述	Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
体外活性	Selgantolimod induces the cellular immune mediators interleukin (IL)-12 and IL-8, as well as the antiviral cytokines tumor necrosis factor-α and interferon-γ in vitro in human peripheral blood mononuclear cells. Selgantolimod-induced cytokines reduce HBV DNA, RNA, and antigen levels in HBV-infected primary human hepatocytes. Selgantolimod activates natural killer and mucosal-associated invariant T cells, stimulates cluster of differentiation (CD)-8+ T-cell proliferation, and increase IFNγ production while lowering programmed cell death protein 1 expression by HBV-specific CD8+-T cells in vitro in peripheral blood mononuclear cells [1].
体内活性	Selgantolimod (p.o., once-weekly) treatment induces dose-dependent increases in serum IL-12 and IL-1 receptor antagonist (IL-1RA) in cynomolgus monkeys and causes functional cure in the woodchuck model of chronic HBV [1].
别名	GS-9688