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DL-Willardiine

Name: DL-Willardiine
Brand: TargetMol
SKU: T50094
Price: 738 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid

货号 T50094Cas号 19772-76-0 一键复制产品信息纯度: 99.99%

很棒

DL-Willardiine (2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid) 是一种非天然氨基酸，谷氨酸的衍生物。它是mGluR5的激动剂，可以调节参与神经递质合成和分解的酶的活性，并影响离子通道和其他膜蛋白的活性。

DL-Willardiine

一键复制产品信息

很棒

纯度: 99.99%

货号 T50094Cas号 19772-76-0

别名 2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid

规格	价格	库存
1 mg	¥ 738	现货
2 mg	¥ 1,110	现货
5 mg	¥ 1,720	现货
10 mg	¥ 2,550	现货
25 mg	¥ 4,060	现货
50 mg	¥ 5,530	现货
100 mg	¥ 7,380	现货
200 mg	¥ 9,990	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.99%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

DL-Willardiine AI Summary

DL-Willardiine exhibits several notable bioactivities. It has a protolysis constant at an ionic strength of 0.1 M with a pKa of 9.3. At a concentration of 100 µM, the compound shows 100% inhibition of specific [3H]AMPA binding to rat brain ionotropic glutamate receptor AMPA membranes. It possesses an IC50 value of 1800.0 nM for inhibiting [3H]AMPA binding and an IC50 value of 97000.0 nM for inhibiting [3H]kainate binding to the respective ionotropic receptors in rat brain membranes. In assays using Sf9 cells, DL-Willardiine demonstrates varying affinities for ionotropic glutamate receptors subtypes, with Ki values of 410.0 nM for iGluR1, 1220.0 nM for iGluR2(R), 14200.0 nM for iGluR4, 19000.0 nM for iGluR3, and significantly lower affinities for iGluR5(Q)1b and iGluR6(V,C,R) subtypes. Additionally, DL-Willardiine acts as an inhibitor of Bloom's syndrome helicase (BLM), with an observed potency of 63,095.7 nM in related assays. These properties indicate the compound's potential roles in modulating glutamatergic neurotransmission and functioning as a BLM inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	DL-Willardiine (2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid) is an unnatural amino acid, a derivative of glutamate. It is an agonist of mGluR5, which regulates the activity of enzymes involved in neurotransmitter synthesis and catabolism, and affects the activity of ion channels and other membrane proteins.
别名	2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid

化学信息

分子量	199.16
分子式	C₇H₉N₃O₄
CAS No.	19772-76-0
Smiles	C(C(C(O)=O)N)N1C(=O)NC(=O)C=C1
密度	1.501 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: < 1.99 mg/mL (10 mM, insoluble or slightly soluble)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.0211 mL	25.1054 mL	50.2109 mL	251.0544 mL
5 mM	1.0042 mL	5.0211 mL	10.0422 mL	50.2109 mL
10 mM	0.5021 mL	2.5105 mL	5.0211 mL	25.1054 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。