Name: Hydroxybupropion
Brand: TargetMol
SKU: T11588
Price: 835 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 835

现货

2 mg

¥ 1,230

现货

5 mg

¥ 1,980

现货

10 mg

¥ 3,230

现货

25 mg

¥ 5,180

现货

50 mg

¥ 7,150

现货

100 mg

¥ 9,630

现货

1 mL x 10 mM (in DMSO)

¥ 1,880

现货

产品介绍

生物活性

产品描述	Hydroxybupropion is the major active metabolite of Bupropion and an antagonist of nACh receptor. Hydroxybupropion inhibits norepinephrine uptake (IC50 = 1.7 μM).
靶点活性	Norepinephrine uptake:1.7 μM
体外活性	Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents[1].
别名	羟基安非他酮, Hydroxybupropione, Hydroxybupropion, (+/-)-, 6-Hydroxybupropion

化学信息

分子量	255.74
分子式	C₁₃H₁₈ClNO₂
CAS No.	92264-81-8
Smiles	C(C(NC(CO)(C)C)C)(=O)C1=CC(Cl)=CC=C1
密度	1.15 g/cm3
颜色	White
物理性状	Solid

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 90 mg/mL (351.92 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.9 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9102 mL	19.5511 mL	39.1022 mL	195.5111 mL
5 mM	0.7820 mL	3.9102 mL	7.8204 mL	39.1022 mL
10 mM	0.3910 mL	1.9551 mL	3.9102 mL	19.5511 mL
20 mM	0.1955 mL	0.9776 mL	1.9551 mL	9.7756 mL
50 mM	0.0782 mL	0.3910 mL	0.7820 mL	3.9102 mL
100 mM	0.0391 mL	0.1955 mL	0.3910 mL	1.9551 mL

体内实验配液计算器