规格

价格

库存

数量

25 mg

¥ 10,600

6-8周

50 mg

¥ 13,800

6-8周

100 mg

¥ 17,500

6-8周

生物活性

产品描述

Antibacterial agent 122 (compound 15) is a thiourea derivative that can be used in the studies of tuberculosis. Antibacterial agent 122 shows low cytotoxicity as well as anti-mycobacterial activity [1].

体外活性

Antibacterial agent 122 (compound 15) (25-200 μM, 24 h) inhibits M. tuberculosis H37Rv with the MIC 50 value of 5.9 μM and inhibits NO production in LPS-stimulated RAW 264.7 cell cultures with an IC 50 value of 8.1μM [1]. Antibacterial agent 122 (compound 15) (25-200 μM) acts on NO scavenging with an IC 50 value of 184.2 μM, and almost completely inhibits iNOS expression in LPS-stimulated RAW264.7 macrophages at a concentration of 100 μM [1]. Antibacterial agent 122 (compound 15) (0-200 μM, 24 h) inhibits TNF-α and IL-1β production in LPS-stimulated macrophages with the IC 50 values of 28.4 μM and 47.9 μM, respectively [1]. Antibacterial agent 122 (compound 15) (25-100 μM, 4 days) inhibits M. tuberculosis M299 with an MIC 50 value of 24.7 μM [1].