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RXFP receptor

RXFP1, or the relaxin family peptide receptor 1, functions as the receptor for relaxin-2, exerting a pivotal influence on the regulation of reproductive and cardiovascular physiology. Recognized as a prominent therapeutic target, RXFP1 holds significance for its substantial impact on various physiological processes. Structurally, RXFP1 is identified as a multi-domain G protein-coupled receptor (GPCR) characterized by an ectodomain that includes an LDLa module and leucine-rich repeats. This intricate structural arrangement underscores the crucial role of RXFP1 in mediating the biological effects of relaxin-2, positioning it as a key player in both physiological and therapeutic contexts.

Cat. No.	Product Name	CAS No.	Purity
T16101	ML-290 化合物ML-290	1482500-76-4	98%
T16101	ML-290 是一个松弛素/胰岛素样肽受体 (RXFP1) 偏向变构激动剂，为抗纤维化基因激活剂，EC50为 94 nM。
T62929	RLX-33 化合物RLX-33	2784577-71-3	99.82%
T62929	RLX-33 是一种有效的、选择性的、能够透过血脑屏障的松弛素家族肽 3 (RXFP3) 拮抗剂，也能够阻断松弛素 3 (relaxin 3) 诱导的 ERK1/2 磷酸化。RLX-33 作用于 RXFP3、ERK1 和 ERK2 磷酸化的 IC50 分别为 2.36 μM、7.82 μM 和 13.86 μM。RLX-...
T63838	AZD5462 化合物AZD5462	2787501-83-9	99.63%
T63838	AZD5462 是一种有效可口服的松弛素受体 RXFP1 激动剂，可用于研究心力衰竭和癌症。
T61964	RXFP3/4 agonist 2 RXFP3/4 激动剂2	2752378-78-0	98%
T61964	RXFP3/4 agonist 2 是一种高效的非肽双 RXFP3/4 激动剂，诱导 RXFP3 和 β-arrestin-2 之间的相互作用，可用于研究代谢异常引起的疾病。