SJG-136 对卵巢细胞系具有细胞毒性，例如 A2780（IC50：22.5 pM）、A2780cisR（IC50：24 pM）、 CH1（IC50：0.12 nM）、CH1cisR（IC50：0.6 nM）以及 SKOV-3（IC50：9.1 nM）。SJG-136 还能降低一系列犬类癌细胞的存活率（GI50：经 1 小时暴露后范围为 0.33 - >100 nM，连续暴露后为 <0.03 - 17.33 nM）[1][2]。

SJG-136-induced H2AX phosphorylation shows good correspondence, but less sensitivity, than measurement of foci. SJG-136 displays a more potent antitumor effect against CMeC-1 tumor at 0.30 mg/kg than 0.15 mg/kg either as a single dose or administered once a week for three weeks via dosed intravenously in mice [2].