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Anti-DNMT1 Polyclonal Antibody
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产品编号 TMAB-00561
别名 MCMT, M.HsaI, EC 2.1.1.37, DNMT, DNA MTase HsaI, DNA methyltransferase HsaI, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, CXXC9, AIM
Anti-DNMT1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DNMT1。Anti-DNMT1 Polyclonal Antibody 可用于 WB。
Anti-DNMT1 Polyclonal Antibody
Anti-DNMT1 Polyclonal Antibody
还可以产品编号 TMAB-00561 别名 MCMT, M.HsaI, EC 2.1.1.37, DNMT, DNA MTase HsaI, DNA methyltransferase HsaI, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, CXXC9, AIM
Anti-DNMT1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 DNMT1。Anti-DNMT1 Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,165 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 | |
| 200 μL | ¥ 2,785 | 5日内发货 |
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产品介绍
生物活性
抗原信息
化学信息
| 产品描述 | Anti-DNMT1 Polyclonal Antibody is a Rabbit antibody targeting DNMT1. Anti-DNMT1 Polyclonal Antibody can be used in WB. |
| 疾病造模方案 | |
| 别名 | MCMT, M.HsaI, EC 2.1.1.37, DNMT, DNA MTase HsaI, DNA methyltransferase HsaI, DNA (cytosine-5)-methyltransferase 1, CXXC-type zinc finger protein 9, CXXC9, AIM |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Sheep) |
| 验证活性 | Sample: Bone (Mouse) Lysate at 40 μg LympHnode (Rat) Lysate at 40 μg Primary: Anti-Dnmt1 (TMAB-00561) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 178 kDa Observed band size: 144 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. |
| 免疫原 | KLH conjugated synthetic peptide: human Dnmt1 |
| 抗原种属 | Human |
| 基因名称 | DNMT1 |
| 基因ID | |
| 蛋白名称 | DNA(cytosine-5)-methyltransferase 1 |
| Uniprot ID | |
| 研究领域 | DNMTs |
| 功能 | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. |
| 分子量 | Theoretical: 178 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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