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Anti-5HT2C Receptor Polyclonal Antibody

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Anti-5HT2C Receptor Polyclonal Antibody
产品编号 TMAB-00010

Anti-5HT2C Receptor Polyclonal Antibody 是一种 Rabbit 抗体,靶向 5HT2C Receptor。Anti-5HT2C Receptor Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-5HT2C Receptor Polyclonal Antibody

Anti-5HT2C Receptor Polyclonal Antibody

Rating icon 还可以
Anti-5HT2C Receptor Polyclonal Antibody
产品编号 TMAB-00010

Anti-5HT2C Receptor Polyclonal Antibody 是一种 Rabbit 抗体,靶向 5HT2C Receptor。Anti-5HT2C Receptor Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-5HT2C Receptor Polyclonal Antibody is a Rabbit antibody targeting 5HT2C Receptor. Anti-5HT2C Receptor Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
交叉反应
Human,Mouse (predicted:Rat,Dog,Pig,Cow,Horse)
验证活性
1. Paraformaldehyde-fixed, paraffin embedded (mouse cerebellum tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with 5HTR2C Polyclonal Antibody, Unconjugated (TMAB-00010) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
2. Sample:
Lane 1: Human SH-SY5Y cell lysates
Lane 2: Human A431 cell lysates
Primary: Anti-5HT2C Receptor (TMAB-00010) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kDa
Observed band size: 59 kDa
应用
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Multi-pass membrane protein.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究背景Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated synthetic peptide: human 5HTR2C
抗原种属
Human
基因ID
Uniprot ID
研究领域
Obesity,Metabolism,Serotonin Receptors,GPCR
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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