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顶部生物活性储存和溶解信息计算器

Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody

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Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody
产品编号 TMAC-00127
别名 p-AKT1/3 (Y437/434), p-AKT1/3 (Tyr437/434), AKT1/3 (p-Y437/434), AKT1/3 (p-Tyr437/434)

Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-AKT1/3 (Tyr437/434)。Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody 可用于 WB,IHC。

Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody

Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody
产品编号 TMAC-00127 别名 p-AKT1/3 (Y437/434), p-AKT1/3 (Tyr437/434), AKT1/3 (p-Y437/434), AKT1/3 (p-Tyr437/434)

Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-AKT1/3 (Tyr437/434)。Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody is a Rabbit antibody targeting Phospho-AKT1/3 (Tyr437/434). Anti-Phospho-AKT1/3 (Tyr437/434) Polyclonal Antibody can be used in WB,IHC.
别名p-AKT1/3 (Y437/434), p-AKT1/3 (Tyr437/434), AKT1/3 (p-Y437/434), AKT1/3 (p-Tyr437/434)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from K562 cells, treated with insulin (0.01U/ml, 15mins), using AKT1/3 (Phospho-Tyr437/434) antibody TMAC-00127. The lane on the right is treated with the synthesized peptide.
2. Immunohistochemistry analysis of paraffin-embedded human brain tissue using AKT1/3 (Phospho-Tyr437/434) antibody TMAC-00127. The picture on the right is treated with the synthesized peptide.
应用
WB
IHC
推荐剂量
WB: 1:500-3000; IHC: 1:50-100
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of tyrosine 437 (T-R-Y(p)-F-D) derived from Human AKT1/3
抗原种属
human
Uniprot ID
P31749 & Q9WUA6-1
化学信息
分子量Actual: 56 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

pAKT1/3 (Y437/434)pAKT1/3 (Tyr437/434)AKT1/3 (pY437/434)AKT1/3 (pTyr437/434)AKT1/3 (phospho-Y437/434)AKT1/3 (phospho-Tyr437/434)

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