store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ceruletide Ammonium Salt 是一种十肽,起源于热带青蛙的皮肤,是一种有效的胆囊收缩素受体 (cholecystokinin receptor) 激动剂,也是一种安全有效的胆囊收缩剂,对胆囊肌肉和胆管有直接的痉挛性作用。Ceruletide Ammonium Salt 具有镇静活性,可用于研究慢性精神分裂症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,830 | 现货 | ||
5 mg | ¥ 5,970 | 现货 | ||
10 mg | ¥ 8,230 | 现货 | ||
25 mg | ¥ 12,200 | 现货 | ||
50 mg | ¥ 16,500 | 现货 | ||
100 mg | ¥ 22,200 | 现货 | ||
500 mg | ¥ 44,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 6,590 | 现货 |
产品描述 | Ceruletide Ammonium Salt is a decapeptide, originating from the skin of tropical frogs, which is a potent cholecystokinin receptor agonist and a safe and effective cholecystokinin receptor agonist with direct spasmodic effects on the gallbladder muscle and bile ducts. Ceruletide Ammonium Salt has sedative activity and has been used in the study of chronic schizophrenia.Ceruletide Ammonium Salt is a decapeptide, originating from the skin of tropical frogs. |
体外活性 | Ceruletide Ammonium Salt shares chemical and biological similarities with the gastrointestinal hormones cholecystokinin (CCK) and gastrin II in humans. Ceruletide Ammonium Salt stimulates gallbladder contraction, pancreatic exocrine secretion, gastric fluid secretion, and motility in the distal duodenum, jejunum, ileum, and colon, while delaying gastric emptying and inhibiting motility in the proximal duodenum[2]. In vitro, Ceruletide Ammonium Salt activates NF-kappaB/Rel at supraphysiological doses rather than at physiological levels. This activation may induce a self-protective genetic program before cell damage occurs, potentially preventing a higher degree of injury to pancreatic acinar cells after excessive stimulation by secretagogues[1]. |
体内活性 |
Ceruletide Ammonium Salt can be utilized for animal modeling, specifically in constructing animal models of pancreatitis. Ceruletide Ammonium Salt (0.4-0.5 μg/kg, intravenous injection; 3-4 μg/kg, subcutaneous injection) induces conscious and complete vomiting and defecation in dogs, with full recovery observed 15-30 minutes and 2-4 hours after intravenous administration or subcutaneous injection, respectively. Ceruletide Ammonium Salt (5-15 ng/kg, intravenous) demonstrates a significant spasmogenic effect on the pylorus in rats. Additionally, Ceruletide Ammonium Salt can reduce blood pressure in anesthetized dogs[2]. Ceruletide Ammonium Salt-stimulated serum bile acids (SBA) evasion eliminates exogenous and endogenous influences associated with postprandial (PP) SBA stimulation. The effectiveness of Ceruletide Ammonium Salt-stimulated SBA in dogs with portosystemic shunts (PSS) may be as good as PP SBA stimulation, and it may be more sensitive in detecting hepatic dysfunction in dogs with upper respiratory disease (URD)[3]. |
别名 | Caerulein Ammonium Salt, Ceruletide Ammonium Salt(17650-98-5 Free base), FI-6934 Ammonium Salt, Cerulein Ammonium Salt |
分子量 | 1370.44 |
分子式 | C58H77N14O21S2 |
store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ceruletide Ammonium Salt GPCR/G Protein cholecystokinin Caerulein Ammonium Salt Ceruletide Ammonium Salt(17650-98-5 Free base) FI-6934 Ammonium Salt 17650-98-5 Cerulein Ammonium Salt 17650-98-5 Free base Inhibitor inhibitor inhibit