cell viability of squamous NSCLC H157 cells inhibited by ABTL-0812 (ABTL0812; 10-100 μM; 48 hours). Compared with squamous NSCLC H157 cells, human lung fibroblast cell line MRC-5 are resistant to ABTL0812 treatment.

In human lung and pancreatic xenografts, ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress. In vivo, ABTL-0812 induces hallmarks of ER stress . ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively.