规格

价格

库存

数量

2 mg

¥ 1,950

现货

5 mg

¥ 2,890

现货

10 mg

¥ 4,160

现货

50 mg

¥ 12,500

现货

100 mg

¥ 17,500

现货

1 mL x 10 mM (in DMSO)

¥ 3,180

现货

生物活性

产品描述	Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist. It has an IC50 of 30 nM in a functional assay with human mGluR5.
靶点活性	mGluR5:30 nM (IC50)
体外活性	Mavoglurant is a selective non-competitive antagonist which showed efficacy in the treatment of L-dopa induced dyskinesias in Parkinson's disease and Fragile X mental retardation in proof of principle studies. Mavoglurant is selective over the other mGluR subtypes, iGluRs and a panel of 238 CNS relevant receptors, transporter, or enzymes.
体内活性	Mavoglurant displays an improved pharmacokinetic profile in rats and efficacy in the stress-induced hyperthermia test in mice as compared to the prototypic mGluR5 antagonist MPEP.[1]
别名	AFQ056

化学信息

分子量	313.39
分子式	C₁₉H₂₃NO₃
CAS No.	543906-09-8
Smiles	C(#CC1=CC(C)=CC=C1)[C@@]2(O)[C@]3([C@](N(C(OC)=O)CC3)(CCC2)[H])[H]
密度	1.21
颜色	White
物理性状	Solid

储存&溶解度

存储

02 | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 47 mg/mL (149.97 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (10.53 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO