规格

价格

库存

数量

1 mg

¥ 2,180

现货

5 mg

¥ 5,370

现货

10 mg

¥ 7,560

现货

25 mg

¥ 11,200

现货

50 mg

¥ 14,900

现货

生物活性

产品描述	dTAGV-1 hydrochloride is a PROTAC-based bifunctional degrader that utilizes the VHL E3 ligase recruitment mechanism to efficiently and selectively induce the in vivo and in vitro degradation of FKBP12F36V-tagged proteins, while having no effect on wild-type FKBP12 protein.
体外活性	dTAGV-1 hydrochloride (0.1 nM-10 μM; 24 h) 可在 293FT 细胞中有效诱导 FKBP12F36V-Nluc 降解，而对 FKBP12WT-Nluc 无影响。[1]
别名	dTAGV-1 盐酸盐

化学信息

分子量	1284.00
分子式	C₆₈H₉₁ClN₆O₁₄S
CAS No.	2624313-16-0
Smiles	[C@@H](OC(=O)[C@H]1N(C([C@@H](CC)C2=CC(OC)=C(OC)C(OC)=C2)=O)CCCC1)(CCC3=CC(OC)=C(OC)C=C3)C4=C(OCC(NCCCCCCC(N[C@H](C(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C=7SC=NC7C)=O)C[C@@H](O)C5)[C@](C)(C)C)=O)=O)C=CC=C4.Cl

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 80 mg/mL (62.31 mM), Sonication is recommended.

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

dTAGV-1 hydrochloride