Name: SB-277011 dihydrochloride
Brand: TargetMol
SKU: T12861L
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 1,080

35日内发货

5 mg

¥ 2,870

35日内发货

10 mg

¥ 4,880

35日内发货

25 mg

¥ 10,800

35日内发货

生物活性

产品描述	SB-277011 dihydrochloride is a potent, selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).
靶点活性	D2 receptor:6 (pki), 5-HT1D receptor:5.9(pki), 5-HT1B receptor:<5.2 (pki), D3 receptor:pki： 8.0
体外活性	SB-277011 dihydrochloride is a selective, orally bioavailable and brain penetrate antagonist of dopamine D3 receptor, and restores ≥100-fold selectivity against the D2, 5-HT1B, and 5-HT1D receptors(pKis of 8.0, 6.0, <5.2 and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively).
体内活性	the effects of quinelorane in the nucleus accumbens completely reversed by SB-277011 dihydrochloride (SB 277011; 3 mg/kg, p.o.), but does not reverse the effects of quinelorane in the striatum at 93 mg/kg in rats.
别名	SB-277011A dihydrochloride

化学信息

分子量	511.49
分子式	C₂₈H₃₂Cl₂N₄O
CAS No.	1226917-67-4
Smiles	N#CC1=CC=C(C(CC2)=C1)CN2CC[C@@H](CC3)CC[C@H]3NC(C4=CC=NC5=C4C=CC=C5)=O.Cl.Cl
密度	1.31g/cm3