规格

价格

库存

数量

1 mg

¥ 778

现货

5 mg

¥ 1,550

现货

10 mg

¥ 2,180

现货

25 mg

¥ 3,690

现货

50 mg

¥ 4,880

现货

100 mg

¥ 6,770

现货

200 mg

¥ 9,130

现货

1 mL x 10 mM (in DMSO)

¥ 2,270

现货

生物活性

产品描述	BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.
靶点活性	CCR2:5.1 nM
体外活性	BMS CCR2 22 inhibits the internalization of hMCP1_AF647 (IC50 = 2 nM)[2]. HAoECs with BMS CCR2 22 before MCP-1 increases the cell surface levels of VCAM-1 from 72.8 to 160% and PECAM1 from 97.2 and 127%[3].

化学信息

分子量	593.66
分子式	C₂₈H₃₄F₃N₅O₄S
CAS No.	445479-97-0
Smiles	CSc1ccc(cc1)C(=O)N[C@@H]1CCCC[C@@H]1NC(=O)CNC(=O)c1cc(ccc1NC(=O)NC(C)C)C(F)(F)F
密度	1.33 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 225 mg/mL (379 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (5.56 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO