Name: AR20.5
Brand: TargetMol
SKU: T9901A-991
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 12,000

待询

5 mg

待询

生物活性

产品描述	AR20.5 represents a highly specialized murine monoclonal antibody specifically engineered to target the tumor-associated antigen MUC1 with exceptional binding affinity. It effectively facilitates the measurable induction of antigen-specific T-cell immune responses across various preclinical experimental models to evaluate the synergy between antibody-mediated vaccination and immune checkpoint blockade during strictly monitored laboratory observation periods and functional tumor challenge assays.
体外活性	在表达 MUC1 的胰腺癌细胞中，AR20.5 联用 PD-L1 阻断剂增强了 T 细胞介导的细胞毒性并增加了 IFN-gamma 的产生 [1]。
体内活性	在受到胰腺肿瘤挑战的 MUC1.Tg 小鼠中，AR20.5 联用抗 PD-L1 显著抑制了肿瘤进展并延长了生存期 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P15941
靶点	MUC1

储存&溶解度

存储	store at low temperature \| -20°C for 2 years, 4°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

AR20.5