Adoprazine

Name: Adoprazine
Brand: TargetMol
SKU: T10249
Price: 477 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.83%

货号 T10249Cas号 222551-17-9

别名 阿哆嗪, SLV313

Adoprazine (SLV313) 是 5-HT 1A 受体的完全激动剂，其在 h5-HT1A 受体的 pEC50 为 9。Adoprazine 是 D2 和 D3 受体的完全拮抗剂，在 hD2 受体中的 pA2 值是 9.3，在 hD3 受体中的 pA2 值是 8.9。Adoprazine 具有非典型抗精神病的特征。

Adoprazine

一键复制产品信息

很棒

纯度: 99.83%

货号 T10249 别名 阿哆嗪, SLV313Cas号 222551-17-9

规格	价格	库存
1 mg	¥ 477	现货
5 mg	¥ 1,160	现货
10 mg	¥ 1,820	现货
25 mg	¥ 3,320	现货
50 mg	¥ 4,970	现货
100 mg	¥ 6,880	现货
1 mL x 10 mM (in DMSO)	¥ 1,030	现货

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COA HNMR LCMS 产品操作手册

产品介绍

Adoprazine AI Summary

Adoprazine exhibits a complex bioactivity profile, including high affinity for the 5HT1A receptor (Ki = 2.291 nM) and moderate affinity for the 5HT2A receptor (Ki = 724.44 nM). It acts as an agonist at the human 5HT1A receptor with an EC50 of 5.888 nM and an Emax of 45.3% relative to serotonin, while also demonstrating antagonist activity against the rat D2 receptor with a pKb of 7.81. In animal studies, it normalizes methylphenidate-induced behaviors in rats (ED50 = 1.4 mg/kg) and induces catalepsy, lower lip retraction, and flat body posture. The compound shows strong affinity for dopamine receptors D2, D3, and D4, moderate affinity for the 5HT2B and 5HT7 receptors, and low affinity for the adrenergic alpha1 receptor. Additionally, Adoprazine displays antiviral activity against SARS-CoV-2 by inhibiting induced cytotoxicity in Caco-2 cells (81.36% inhibition at 10 µM, IC50 = 18590.0 nM, CC50 = 75900.0 nM, selectivity index of 4.0). It also inhibits the SARS-CoV-2 3CL-Pro protease by 21.78% at 20 µM and demonstrates variable inhibitory effects on human HDAC6, with -30.81% inhibition using a commercial peptide substrate and 2.0% inhibition with a custom peptide substrate. Furthermore, the compound exhibits minimal antiviral activity in VERO-6 cells (-0.09% inhibition at 10 µM)..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Adoprazine (SLV313) is a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties.
靶点活性	D4 Receptor:8.0 (pKi), D3 receptor:8.4 (pKi), D3 receptor:8.9 (pA2), 5-HT7 receptor:7.2 (pKi), 5-HT1A receptor:9.1 (pKi), 5-HT1A receptor:9 (pEC50), D2 Receptor:9.3 (pA2), D2 Receptor:8.4 (pKi)
别名	阿哆嗪, SLV313

化学信息

分子量	405.46
分子式	C₂₄H₂₄FN₃O₂
CAS No.	222551-17-9
Smiles	Fc1ccc(cc1)-c1cncc(CN2CCN(CC2)c2cccc3OCCOc23)c1
密度	1.256 g/cm3
颜色	Yellow
物理性状	Solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (110.99 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.17 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4663 mL	12.3317 mL	24.6633 mL	123.3167 mL
5 mM	0.4933 mL	2.4663 mL	4.9327 mL	24.6633 mL
10 mM	0.2466 mL	1.2332 mL	2.4663 mL	12.3317 mL
20 mM	0.1233 mL	0.6166 mL	1.2332 mL	6.1658 mL
50 mM	0.0493 mL	0.2466 mL	0.4933 mL	2.4663 mL
100 mM	0.0247 mL	0.1233 mL	0.2466 mL	1.2332 mL