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Vofopitant dihydrochloride

Name: Vofopitant dihydrochloride
Brand: TargetMol
SKU: T13329L
Price: 1070 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.99%

货号 T13329LCas号 168266-51-1

别名 沃弗呲坦盐酸盐, Vofopitant 2HCl, GR 205171A

Vofopitant dihydrochloride (GR 205171A) 是一种可口服且具有选择性的速激肽 NK1 受体拮抗剂，对 [3H]SP 与 NK1 结合有抑制作用， pKi 值分别为 9.5 和 10.6。Vofopitant dihydrochloride 是治疗病理性呕吐的潜在化合物。

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Vofopitant dihydrochloride

一键复制产品信息

很棒

纯度: 98.99%

货号 T13329L 别名 沃弗呲坦盐酸盐, Vofopitant 2HCl, GR 205171ACas号 168266-51-1

规格	价格	库存
1 mg	¥ 1,070	现货
2 mg	¥ 1,530	现货
5 mg	¥ 2,480	现货
10 mg	¥ 3,980	现货
25 mg	¥ 6,270	现货
50 mg	¥ 8,460	现货
100 mg	¥ 11,300	现货
1 mL x 10 mM (in DMSO)	¥ 2,760	现货

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常见问题解答

选择批次:

纯度: 98.99%

ee: 100%

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资源下载:

COA CSFC HNMR LCMS 产品操作手册

产品介绍

Vofopitant dihydrochloride AI Summary

Vofopitant dihydrochloride exhibits potent bioactivities related to its interaction with the human NK1 receptor, showing a high affinity with a Ki value of 0.02512 nM, indicative of its ability to efficiently displace [125I]BH-SP from the receptor in human IM9 cells. Additionally, the compound demonstrates in vivo antiemetic activity against radiation-induced emesis in ferrets, with an effective dose (ED90) of 0.03 mg kg-1, suggesting potential therapeutic applications for NK1 receptor modulation..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Vofopitant dihydrochloride (GR 205171A) is an orally available, selective tachykinin NK1 receptor antagonist that inhibits [3H]SP binding to NK1 with pKi values of 9.5 and 10.6, respectively.Vofopitant dihydrochloride is a potential compound for the treatment of pathological vomiting. Vofopitant dihydrochloride is a potential compound for the treatment of pathological vomiting.
靶点活性	NK1 (rat):9.5 (pKi), NK1 (human):10.6 (pKi)
别名	沃弗呲坦盐酸盐, Vofopitant 2HCl, GR 205171A

化学信息

分子量	505.36
分子式	C₂₁H₂₅Cl₂F₃N₆O
CAS No.	168266-51-1
Smiles	Cl.Cl.COc1ccc(cc1CN[C@H]1CCCN[C@H]1c1ccccc1)-n1nnnc1C(F)(F)F
密度	no data available
颜色	White
物理性状	Solid

储存&溶解度

存储

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

H2O: 20 mg/mL (39.58 mM), Sonication is recommended.

DMSO: 20 mg/mL (39.58 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.96 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9788 mL	9.8939 mL	19.7879 mL	98.9394 mL
5 mM	0.3958 mL	1.9788 mL	3.9576 mL	19.7879 mL
10 mM	0.1979 mL	0.9894 mL	1.9788 mL	9.8939 mL
20 mM	0.0989 mL	0.4947 mL	0.9894 mL	4.9470 mL