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Anti-Caspase-8 Antibody (4B478)

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Anti-Caspase-8 Antibody (4B478)
产品编号 TMAC-00591
别名 OTTHUMP00000206582, OTTHUMP00000206552, OTTHUMP00000165064, OTTHUMP00000165063, OTTHUMP00000165062, OTTHUMP00000163725, OTTHUMP00000163724, OTTHUMP00000163720, OTTHUMP00000163717, MORT1 associated CED 3 homolog, MGC78473, MCH5, MCH 5, MACH beta 1/2/3/4 protein, MACH alpha 1/2/3 protein, MACH, ICE like apoptotic protease 5, FLJ17672, FLICE, FADD-like ICE, FADD-homologous ICE/ced-3-like protease, FADD Like ICE, FADD Homologous ICE/CED3 Like Protease, FADD homologous ICE/CED 3 like protease, CED 3, Caspase-8 subunit p18, Caspase8, Caspase 8 apoptosis related cysteine peptidase, Caspase 8, CASP8, CASP 8, CAP4, CAP 4, Apoptotic protease Mch-5, Apoptotic protease Mch 5, Apoptotic cysteine protease, Apoptosis related cysteine peptidase, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein, ALPS2B

Anti-Caspase-8 Antibody (4B478) 是一种 Rabbit 抗体，靶向 Caspase-8。Anti-Caspase-8 Antibody (4B478) 可用于 WB,ICC/IF,IHC。

Anti-Caspase-8 Antibody (4B478)

Anti-Caspase-8 Antibody (4B478)

Rating icon 还可以
Anti-Caspase-8 Antibody (4B478)
产品编号 TMAC-00591 别名 OTTHUMP00000206582, OTTHUMP00000206552, OTTHUMP00000165064, OTTHUMP00000165063, OTTHUMP00000165062, OTTHUMP00000163725, OTTHUMP00000163724, OTTHUMP00000163720, OTTHUMP00000163717, MORT1 associated CED 3 homolog, MGC78473, MCH5, MCH 5, MACH beta 1/2/3/4 protein, MACH alpha 1/2/3 protein, MACH, ICE like apoptotic protease 5, FLJ17672, FLICE, FADD-like ICE, FADD-homologous ICE/ced-3-like protease, FADD Like ICE, FADD Homologous ICE/CED3 Like Protease, FADD homologous ICE/CED 3 like protease, CED 3, Caspase-8 subunit p18, Caspase8, Caspase 8 apoptosis related cysteine peptidase, Caspase 8, CASP8, CASP 8, CAP4, CAP 4, Apoptotic protease Mch-5, Apoptotic protease Mch 5, Apoptotic cysteine protease, Apoptosis related cysteine peptidase, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein, ALPS2B

Anti-Caspase-8 Antibody (4B478) 是一种 Rabbit 抗体，靶向 Caspase-8。Anti-Caspase-8 Antibody (4B478) 可用于 WB,ICC/IF,IHC。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,480
5日内发货
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产品描述
Anti-Caspase-8 Antibody (4B478) is a Rabbit antibody targeting Caspase-8. Anti-Caspase-8 Antibody (4B478) can be used in WB,ICC/IF,IHC.
别名OTTHUMP00000206582, OTTHUMP00000206552, OTTHUMP00000165064, OTTHUMP00000165063, OTTHUMP00000165062, OTTHUMP00000163725, OTTHUMP00000163724, OTTHUMP00000163720, OTTHUMP00000163717, MORT1 associated CED 3 homolog, MGC78473, MCH5, MCH 5, MACH beta 1/2/3/4 protein, MACH alpha 1/2/3 protein, MACH, ICE like apoptotic protease 5, FLJ17672, FLICE, FADD-like ICE, FADD-homologous ICE/ced-3-like protease, FADD Like ICE, FADD Homologous ICE/CED3 Like Protease, FADD homologous ICE/CED 3 like protease, CED 3, Caspase-8 subunit p18, Caspase8, Caspase 8 apoptosis related cysteine peptidase, Caspase 8, CASP8, CASP 8, CAP4, CAP 4, Apoptotic protease Mch-5, Apoptotic protease Mch 5, Apoptotic cysteine protease, Apoptosis related cysteine peptidase, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein, ALPS2B
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of Caspase-8 on different lysates using anti-Caspase-8 antibody at 1/1,000 dilution. Positive control: Lane 1: Jurkat, Lane 2: Hela.
2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Caspase-8 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-Caspase-8 antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Caspase-8 antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Caspase-8 antibody. Counter stained with hematoxylin.
6. ICC staining Caspase-8 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
7. ICC staining Caspase-8 in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC/IF
IHC
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Initiator caspases, which include caspase-8, activate effector caspases by cleaving inactive forms of effector caspases. In the activation cascade responsible for apoptosis induced by TNFRSF1A and mediated by TNFRSF6/FAS, caspase-8 is the most upstream protease. Caspase-8 binds to adaptor molecule FADD, forming an aggregate referred to as death-inducing signaling complex (DISC), which activates caspase-8. The actived protein is released from the complex and further activates downstream apoptotic proteases. Caspase-8, which is a heterodimer consisting of two subunits (p18 and p10), is widely expressed, but is detected at highest levels in peripheral blood leukocytes (PBLs), thymus, liver and spleen. Defects in CASP8, the gene encoding for caspase-8, may cause CASP8D (caspase-8 deficiency disorder), which is characterized by splenomegaly and CD95-induced apoptosis of PBLs, may lead to immunodeficiency due to defects in T lymphocyte, NK cell and B lymphocyte activation.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q14790
化学信息
分子量Theoretical: 55/46 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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