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Anti-EEA1 Antibody (2X782)

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Anti-EEA1 Antibody (2X782)
产品编号 TMAC-01228
别名 Zinc finger FYVE domain-containing protein 2, ZFYVE2, MSTP105, MST105, Endosome-associated protein p162, EEA1, EEA 1, Early endosome associated protein, Early endosome antigen 1, 162kD, Early endosome antigen 1

Anti-EEA1 Antibody (2X782) 是一种 Mouse 抗体，靶向 EEA1。Anti-EEA1 Antibody (2X782) 可用于 WB,ICC,IHC。

Anti-EEA1 Antibody (2X782)

Anti-EEA1 Antibody (2X782)

Rating icon 还可以
Anti-EEA1 Antibody (2X782)
产品编号 TMAC-01228 别名 Zinc finger FYVE domain-containing protein 2, ZFYVE2, MSTP105, MST105, Endosome-associated protein p162, EEA1, EEA 1, Early endosome associated protein, Early endosome antigen 1, 162kD, Early endosome antigen 1

Anti-EEA1 Antibody (2X782) 是一种 Mouse 抗体，靶向 EEA1。Anti-EEA1 Antibody (2X782) 可用于 WB,ICC,IHC。

规格价格库存数量
50 μL
¥ 1,990
5日内发货
100 μL
¥ 2,985
5日内发货
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产品介绍

生物活性
产品描述
Anti-EEA1 Antibody (2X782) is a Mouse antibody targeting EEA1. Anti-EEA1 Antibody (2X782) can be used in WB,ICC,IHC.
别名Zinc finger FYVE domain-containing protein 2, ZFYVE2, MSTP105, MST105, Endosome-associated protein p162, EEA1, EEA 1, Early endosome associated protein, Early endosome antigen 1, 162kD, Early endosome antigen 1
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis on 293 cell lysates using anti-EEA1 mouse mAb.
2. ICC staining EEA1 in Hela cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining EEA1 in A431 cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC
IHC
推荐剂量
WB: 1:2000-5000; ICC: 1:100
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景EEA1 localizes exclusively to early endosomes?and has an important role in endosomal trafficking. EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate?through its C-terminalFYVE domain?and forms a homodimer?through a?coiled coil. EEA1 acts as a tethering molecule that couples vesicle docking with SNAREs such as?N-ethylmaleimide sensitive fusion protein, bringing the endosomes physically closer and ultimately resulting in the fusion and delivery of endosomal cargo. Due to the proteins importance in vesicular trafficking, a number of intracellular bacteria prevent EEA1 recruitment to the vacuole.Mycobacterium tuberculosis?is known to inhibit the recruitment of EEA1 to the phagosomal membrane through CamKII. Legionella pneumophila?also prevents EEA1 recruitment through a currently unknown mechanism.[5] Interestingly, the related pathogen Legionella longbeachae?recruits EEA1 and appears to replicate within a modified early endosome.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Peptide
Uniprot ID
Q15075
化学信息
分子量Theoretical: 162 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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