Name: Antitumor agent-143
Brand: TargetMol
SKU: T209381
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

生物活性

产品描述	Antitumor agent-143 (compound 2c) is an antitumor agent that inhibits cell proliferation during the S phase in A549 cells and induces early apoptosis (apoptosis). It leads to cell death via ferroptosis (ferroptosis), apoptosis through ROS-mediated mitochondrial dysfunction, and pyroptosis (pyroptosis) mediated by GSDMD.
体外活性	Antitumor agent-143（compound 2c；48h）能够抑制A549、B16、HCT116和HepG2细胞的生长，IC50值分别为2.2 μM、2.5 μM、2.5 μM和1 μM。该化合物可阻止A549细胞在S期的增殖并诱导早期细胞凋亡。同时，Antitumor agent-143 (compound 2c) 导致ROS和Ca2+水平升高，引起线粒体膜电位下降、线粒体通透性转换孔开放以及细胞色素c增加。
体内活性	化合物2c（Antitumor agent-143）使小鼠的肿瘤体积缩小。