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ST-193 hydrochloride (489416-12-8 free base)
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产品编号 T13006L
别名 ST-193 hydrochloride
ST-193 hydrochloride is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively).
ST-193 hydrochloride (489416-12-8 free base)
还可以产品编号 T13006L 别名 ST-193 hydrochloride
ST-193 hydrochloride is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively).
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 mg | ¥ 3,010 | 待询 | |
| 10 mg | ¥ 5,135 | 待询 | |
| 25 mg | ¥ 10,235 | 待询 | |
| 50 mg | ¥ 16,610 | 待询 | |
| 100 mg | ¥ 28,935 | 待询 | |
| 200 mg | 待询 | 待询 | |
| 500 mg | 待询 | 待询 | |
| 1 mL x 10 mM (in DMSO) | ¥ 3,110 | 待询 |
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| 产品描述 | ST-193 hydrochloride is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively). |
| 靶点活性 | Machupo:3.1 nM , Guanarito:0.44 nM , Lassa:1.4 nM , Junin:0.62 nM |
| 体外活性 | LASV pseudotypes(IC50 of 1.6 nM)inhibited by ST-193 . ST-193 inhibits pseudotypes generated with other arenavirus envelopes as well, including the remaining four commonly associated with hemorrhagic fever (IC50s for Junín, Machupo, Guanarito, and Sabiá were in the 0.2 to 12 nM range)[2]. |
| 体内活性 | Compared to the ribavirin or vehicle groups, ST-193-treated animals exhibit fewer signs of disease and enhance survival . Body temperatures in all groups are elevated by day 9, but returned to normal by day 19 postinfection in the majority of ST-193-treated animals. ST-193 treatment mediates a 2- to 3-log reduction in viremia relative to vehicle-treated controls. The overall survival rate for the ST-193-treated guinea pigs is 62.5% (10/16) compared with 0% in the ribavirin (0/8) and vehicle (0/7) groups[3]. |
| 别名 | ST-193 hydrochloride |
| 分子量 | 407.94 |
| 分子式 | C24H26ClN3O |
| 密度 | no data available |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 150 mg/mL (367.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 一共给药动物 10 只 ，您使用的配方为 5% 
DMSO+ 30%PEG300+ 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为 2 mg/mL 。 体内配方的制备方法: 取 50μLDMSO 母液，添加 300 μLPEG300 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2O 混匀澄清
母液，添加 300 μLPEG300 混匀澄清，再加 50μLTween 80, 混匀澄清，再加 600μLSaline/PBS/ddH2O 混匀澄清 以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
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对于不同动物的给药剂量换算，您也可以参考 更多
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