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azido-FTY720

azido-FTY720

产品编号 T37548   CAS 881914-35-8
别名: azido-FTY720

FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.

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azido-FTY720 Chemical Structure
azido-FTY720, CAS 881914-35-8
规格 价格/CNY 货期 数量
100 μg ¥ 577 35日内发货
500 μg ¥ 2,500 35日内发货
1 mg ¥ 4,440 35日内发货
5 mg ¥ 19,300 35日内发货
药物设计专题培训
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
产品目录号及名称: azido-FTY720 (T37548)
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产品描述 FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. azido-FTY720 is a highly photoreactive analog of FTY720 that can be used to identify receptor binding sites for this ligand.
别名 azido-FTY720
分子量 348.491
分子式 C19H32N4O2
CAS No. 881914-35-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 20 mg/mL

DMF: 20 mg/mL

DMSO: 20 mg/mL

Ethanol:PBS (pH 7.2) (1:1): 0.2 mg/mL

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体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

azido-FTY720 881914-35-8 azido-FTY 720 azido FTY720 azidoFTY720 azido-FTY-720 Inhibitor inhibitor inhibit

 

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