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Anti-KRT14 Antibody (3N758)
还可以产品编号 TMAY-00068
Anti-KRT14 Antibody (3N758) 是一种 Mouse 抗体，靶向 KRT14。Anti-KRT14 Antibody (3N758) 可用于 IHC-P。
Anti-KRT14 Antibody (3N758)
Anti-KRT14 Antibody (3N758)
还可以产品编号 TMAY-00068
Anti-KRT14 Antibody (3N758) 是一种 Mouse 抗体，靶向 KRT14。Anti-KRT14 Antibody (3N758) 可用于 IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-KRT14 Antibody (3N758) is a Mouse antibody targeting KRT14. Anti-KRT14 Antibody (3N758) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 3N758 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human KRT14 in human skin with mouse monoclonal antibody (1:20000, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human KRT14 in human esophageal carcinoma with mouse monoclonal antibody (1:20000, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:10000-1:20000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cytokeratin 14, also known as Keratin 14 and K14, is a member of the keratin family. Cytokeratin 14 is a type I keratin. It is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Cytokeratin 14 is mainly expressed in the basal layer. It is also strongly expressed in the outer root sheath of anagen follicles. Cytokeratin 14 and keratin 5 may have a role in the maintenance of cell proliferation potential in the basal layer of stratified epithelia, modulating phosphatidylinositol 3-kinase/Akt–mediated cell proliferation and/or Notch1-dependent cell differentiation. Cytokeratin 14 defect prevents it from working effectively with keratin 5 and interfering with the assembly of the keratin intermediate filament network. A disruption in this network makes keratinocytes fragile and prone to rupture. Minor trauma to the skin, such as rubbing or scratching, can cause these cells to break down, resulting in the formation of painful, fluid-filled blisters. Mutations in the K14 gene are also responsible for Naegeli-Franceschetti-Jadassohn syndrome and Dermatopathia Pigmentosa Reticularis. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the C-terminus of the Human Cytokeratin 14/KRT14 |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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