Amrinone

Name: Amrinone
Brand: TargetMol
SKU: T1265
Price: 178 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.45%

货号 T1265Cas号 60719-84-8

别名 氨力农, Wincoram, Inocor, Inamrinone

Amrinone (Inocor) 是一种正性肌力血管扩张剂，是一种具有口服活性的，非糖苷和非儿茶酚胺的强心剂，也是一种选择性磷酸二酯酶 III (phosphodiesterase III) 抑制剂，能够防止环磷酸腺苷分解，从而增加环磷酸腺苷水平。

Amrinone

一键复制产品信息

很棒

纯度: 99.45%

货号 T1265 别名 氨力农, Wincoram, Inocor, InamrinoneCas号 60719-84-8

规格	价格	库存
50 mg	¥ 247	现货
100 mg	¥ 372	现货
200 mg	¥ 538	现货
500 mg	¥ 892	现货
1 mL x 10 mM (in DMSO)	¥ 178	现货

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纯度: 98.88%

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COA LCMS HNMR HPLC 产品操作手册

产品介绍

Amrinone AI Summary

Amrinone exhibits positive inotropic activity in both anesthetized dogs (ED50 = 0.389 mg/kg) and isolated papillary muscle of dogs, indicating an increase in myocardial contractility. It inhibits various forms of phosphodiesterase (PDE) with notable inhibitory concentrations (IC50 values) including: - PDE3 from guinea pig heart: IC50 = 50000.0 nM - PDE3 in dog aorta: IC50 = 28000.0 nM - PDE4 from the heart: IC50 = 101000.0 nM - PDE1 from the cerebral cortex: IC50 > 300000.0 nM The compound also significantly affects contractile force and frequency rate in spontaneous beating atria from Reserpine-treated guinea pigs, demonstrating an increase in both parameters at different concentrations. It has bioactivities related to hemodynamic activity, showing a dose-dependent increase in left ventricular myocardial activity in anesthetized dogs, and exhibits a significant inhibitory effect on ADP-induced platelet aggregation at higher concentrations. Additionally, Amrinone has moderate lipophilicity with a LogP value of 2.66 and shows good oral bioavailability in humans (>80%). The compound's pharmacokinetic profile indicates a high clearance rate (8.9 mL.min^-1.kg^-1) and a short half-life (T1/2 = 2.0 hr), suggesting a relatively short duration of action. On the cardiovascular side, it also demonstrates selectivity and potency against cAMP PDE III enzyme over PDE I and II, and shows significant liver metabolism markers, with effects observed on enzymes such as SGOT and SGPT. Furthermore, the compound's inhibition of human BSEP activity and its interaction with various transporters like P-gp and MRP2 hints at its complex absorption and distribution characteristics. In antiviral contexts, it shows marginal activity against SARS-CoV-2 induced cytotoxicity in Caco-2 cells, suggesting a limited antiviral potential. Overall, Amrinone demonstrates promising cardiotonic properties and PDE inhibition but requires further evaluation for its multi-target bioactivities, including its antiviral potential and liver toxicity profile..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
别名	氨力农, Wincoram, Inocor, Inamrinone

化学信息

分子量	187.2
分子式	C₁₀H₉N₃O
CAS No.	60719-84-8
Smiles	NC1=CC(=CNC1=O)C=2C=CN=CC2
密度	1.277 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 10 mg/mL (53.42 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (5.34 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3419 mL	26.7094 mL	53.4188 mL	267.0940 mL
5 mM	1.0684 mL	5.3419 mL	10.6838 mL	53.4188 mL
10 mM	0.5342 mL	2.6709 mL	5.3419 mL	26.7094 mL
20 mM	0.2671 mL	1.3355 mL	2.6709 mL	13.3547 mL
50 mM	0.1068 mL	0.5342 mL	1.0684 mL	5.3419 mL