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Clofibrate

Name: Clofibrate
Brand: TargetMol
SKU: T1298
Price: 153 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 98.77%

货号 T1298Cas号 637-07-0

别名 氯贝丁酯, Ethyl clofibrate, Clofibratum, Clofibrato

Clofibrate (Clofibrato) 是芳氧基异丁酸衍生物，具有抗高血脂活性。它是一种 PPAR 的激动剂，对人和鼠 PPARα 和 PPARγ 的 EC50值分别为 55 μM，约500 μM 和 50 μM，约500 μM。

Clofibrate

一键复制产品信息

很棒

纯度: 98.77%

货号 T1298 别名 氯贝丁酯, Ethyl clofibrate, Clofibratum, ClofibratoCas号 637-07-0

规格	价格	库存
100 mg	¥ 153	现货
500 mg	¥ 328	现货
1 g	¥ 396	现货
5 g	¥ 556	现货
1 mL x 10 mM (in DMSO)	¥ 413	现货

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纯度: 98.77%

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COA LCMS GC HNMR 产品操作手册

产品介绍

Clofibrate AI Summary

Clofibrate exhibits a broad spectrum of bioactivities with significant potential in lipid metabolism and liver health management. It demonstrates notable hypolipidemic activity by significantly lowering plasma triglycerides and total cholesterol levels in both hypercholesterolemic and normocholesterolemic rat models. For instance, in cholesterol-fed rats at a 200 mg/kg dose over 3 days, it reduced plasma triglycerides by 10.0%, total cholesterol by 30.0%, and HDL cholesterol by 10.0%. In addition to its hypolipidemic properties, Clofibrate also shows promising antioxidant and hepatoprotective effects. It decreases serum lipid peroxidation levels and enhances antioxidant enzymes like CAT, MDA, and SOD in serum and liver tissues. The compound further demonstrates hypoglycemic activity in KK-mice and significant impacts on enzyme activities related to lipid metabolism, including inhibition of HMG-CoA reductase and enhancement of liver microsomal protein levels. Clofibrate affects plasma lipoprotein ratios, increases liver weight, and shows inhibition of cholesterol and fatty acid biosynthesis, indicating its broader implications on liver function and lipid storage. Additionally, it exhibits considerable binding affinity and inhibitory action against various enzymes and receptors, including human PPAR alpha and gamma, DRD1, and multiple cytochrome P450 isoforms. While these bioactivities suggest therapeutic potential, Clofibrate also shows some toxicity at higher doses, such as a dose-dependent increase in liver weight and minor hepatotoxicity in specific rat models. It exhibits moderate effects against SARS-CoV-2 induced cytotoxicity, highlighting its versatile bioactivity profile but with limited antiviral potency. Overall, Clofibrate presents potential applications in managing dyslipidemia, enhancing antioxidant defense, and possibly modulating lipid-related metabolic pathways, with considerations for its dose-dependent toxicity..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.
靶点活性	PPARγ (human):500 μM (ec50), PPARα (human):55 μM(ec50), PPARγ (murine):500 μM (ec50), PPARα (murine):50 μM (ec50)
别名	氯贝丁酯, Ethyl clofibrate, Clofibratum, Clofibrato

化学信息

分子量	242.70
分子式	C₁₂H₁₅ClO₃
CAS No.	637-07-0
Smiles	CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1
密度	1.14g/mLat 25°C(lit.)

储存&溶解度

存储

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (206.02 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.24 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1203 mL	20.6016 mL	41.2031 mL	206.0157 mL
5 mM	0.8241 mL	4.1203 mL	8.2406 mL	41.2031 mL
10 mM	0.4120 mL	2.0602 mL	4.1203 mL	20.6016 mL
20 mM	0.2060 mL	1.0301 mL	2.0602 mL	10.3008 mL
50 mM	0.0824 mL	0.4120 mL	0.8241 mL	4.1203 mL
100 mM	0.0412 mL	0.2060 mL	0.4120 mL	2.0602 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

PPARα PPAR Clofibrate

Clofibrate

Clofibrate

Clofibrate 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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