NC1153 is a blocker of IL-2-induced activation of JAK3 and its downstream substrates STAT5a b. It promotes long-term allograft survival and sparing the recipient from multiple toxicities.
NC1 is a novel highly active allosteric inhibitor of protein tyrosine phosphatase, non-receptor type 22 (PTPN22) which is a lymphoid-specific tyrosine phosphatase (LYP).
NC190 is an inhibitor of topoisomerase II that inhibited the growth of FM3A cells in clinical trials. NC-190 strongly inhibited the growth of FM3A cells when cultured with NC-190 for 48 h (IC50: 0.019 μg ml). NC-190 potently suppressed DNA synthesis with
UCSF924NC is the recommended negative control compound for the high-affinity dopamine D4 receptor (DRD4) partial agonist UCSF924. UCSF924NC exhibits a 1 2500-fold reduced D4 affinity when compared with that of UCSF924.