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RANK/TNFRSF11A Protein, Human, Recombinant (hFc)

RANK/TNFRSF11A Protein, Human, Recombinant (hFc)

产品编号 TMPY-04142
别名: OPTB7, OFE, OSTS, LOH18CR1, FEO, TRANCER, tumor necrosis factor receptor superfamily member 11a, TNFRSF11A, CD265, ODFR, RANK, PDB2

RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3.

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RANK/TNFRSF11A Protein, Human, Recombinant (hFc)
规格 价格/CNY 货期 数量
100 μg ¥ 4,470 现货
200 μg ¥ 7,530 5日内发货
500 μg ¥ 14,970 5日内发货
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产品目录号及名称: RANK/TNFRSF11A Protein, Human, Recombinant (hFc) (TMPY-04142)
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生物活性
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参考文献
生物活性 Measured by its ability to inhibit TRANCE-induced osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED50 for this effect is 3-16ng/mL in the presence of 5 ng/mL of TRANCE.
产品描述 RANK/TNFRSF11A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.8 kDa and the accession number is Q9Y6Q6-3.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 Q9Y6Q6-3
别名 OPTB7, OFE, OSTS, LOH18CR1, FEO, TRANCER, tumor necrosis factor receptor superfamily member 11a, TNFRSF11A, CD265, ODFR, RANK, PDB2
蛋白构建 The Human TNFRSF11A (NP_001257879.1) (Met1-Pro212) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度 > 90 % as determined by SDS-PAGE
分子量 46.8 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 TNFRSF11A is a member of the TNF-receptor superfamily. In mouse, it is also known as CD265. TNFRSF11A contains 4 TNFR-Cys repeats and is widely expressed with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. It is an essential mediator for osteoclast and lymph node development. TNFRSF11A and its ligand are important regulators of the interaction between T cells and dendritic cells. It can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. Defects in TNFRSF11A can cause familial expansile osteolysis (FEO). FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. Defects in TNFRSF11A also can cause Paget disease of bone type 2 (PDB2). PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Defects in TNFRSF11A are the cause of osteopetrosis autosomal recessive type 7 which characterized by abnormally dense bone, due to defective resorption of immature bone.

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Keywords

RANK/TNFRSF11A Protein, Human, Recombinant (hFc) OPTB7 PDB-2 OFE PDB 2 OSTS LOH18CR1 FEO OPTB-7 TRANCER OPTB 7 tumor necrosis factor receptor superfamily member 11a CD-265 TNFRSF11A CD265 ODFR CD 265 RANK PDB2 recombinant recombinant-proteins proteins protein

 

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