Anti-SMN1 Antibody (1X93)

Name: Anti-SMN1 Antibody (1X93)
Brand: TargetMol
SKU: TMAH-01112
Rating: 4.5 (1 reviews)

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产品编号 TMAH-01112

别名 Survival motor neuron protein, SMNT, SMNC, SMN2, SMN 1, SMN, Gemin-1, Component of gems 1

Anti-SMN1 Antibody (1X93) 是一种抗体，靶向 SMN1。Anti-SMN1 Antibody (1X93) 可用于 ELISA, IHC。

Anti-SMN1 Antibody (1X93)

还可以

产品编号 TMAH-01112 别名 Survival motor neuron protein, SMNT, SMNC, SMN2, SMN 1, SMN, Gemin-1, Component of gems 1

Anti-SMN1 Antibody (1X93) 是一种抗体，靶向 SMN1。Anti-SMN1 Antibody (1X93) 可用于 ELISA, IHC。

规格	价格	库存	数量
50 μL	¥ 1,300	5日内发货
100 μL	¥ 2,180	5日内发货

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产品描述	Anti-SMN1 Antibody (1X93) is an antibody targeting SMN1. Anti-SMN1 Antibody (1X93) can be used in ELISA, IHC.
别名	Survival motor neuron protein, SMNT, SMNC, SMN2, SMN 1, SMN, Gemin-1, Component of gems 1
Ig Type	Rabbit IgG
克隆号	1X93
交叉反应	Human
验证活性	IHC image of TMAH-01112 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
应用	ELISA, IHC
推荐剂量	IHC:1:50-1:200.
抗体种类	Monoclonal
亚细胞定位	Nucleus, gem. Nucleus, Cajal body. Cytoplasm. Cytoplasmic granule. Perikaryon. Cell projection, neuron projection. Cell projection, axon. Cytoplasm, myofibril, sarcomere, Z line.
构建方式	Recombinant Antibody
纯化方式	Affinity-chromatography
性状	Liquid
缓冲液	Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景	The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Within the SMN complex, SMN1 acts as a structural backbone and together with GEMIN2 it gathers the Sm complex subunits. Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	A synthetic peptide: Human SMN1
抗原种属	Human
基因ID	6606
Uniprot ID	Q16637
研究领域	Epigenetics and Nuclear Signaling, Neuroscience, Signal transduction