购物车

您的购物车当前为空

Naringenin chalcone

Name: Naringenin chalcone
Brand: TargetMol
SKU: T7784
Price: 413 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 柚皮素查耳酮, Isosalipurpol, Chalcononaringenin, Chalconaringenin, 2',4,4',6'-TETRAHYDROXYCHALCONE

货号 T7784Cas号 25515-46-2 一键复制产品信息纯度: 99.58%

很棒

Naringenin chalcone是分离自植物Machaerium isadelphum (Fabaceae)茎中的天然产物.Naringenin chalcone 具有抗炎活性。

Naringenin chalcone

一键复制产品信息

很棒

纯度: 99.58%

货号 T7784Cas号 25515-46-2

别名 柚皮素查耳酮, Isosalipurpol, Chalcononaringenin, Chalconaringenin, 2',4,4',6'-TETRAHYDROXYCHALCONE

Naringenin chalcone是分离自植物Machaerium isadelphum (Fabaceae)茎中的天然产物.Naringenin chalcone 具有抗炎活性。

规格	价格	库存
1 mg	¥ 413	现货
2 mg	¥ 556	现货
5 mg	¥ 828	现货
10 mg	¥ 1,330	现货
25 mg	¥ 2,230	现货
50 mg	¥ 3,330	7日内发货
100 mg	¥ 4,770	7日内发货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

大包装 & 定制

加入购物车

TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.58%

颜色: 黄色至橙色

性状: Solid

联系我们获取更多批次信息

资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

Naringenin chalcone AI Summary

Naringenin chalcone exhibits a diverse range of biological activities. It has a binding affinity to the P-Glycoprotein C-terminal cytosolic domain with a Kd of 4800.0 nM and maximal fluorescence quenching of 86.8%. The compound shows in vitro inhibition against 5-lipoxygenase in RBL-1 cells (IC50 = 100,000.0 nM) and inhibits Prostaglandin G/H synthase activity in sheep seminal vesicle (3.1% inhibition). It also inhibits lipid peroxidation in rat liver microsomes at 1 µM (8.0% inhibition). In terms of antiproliferative effects, Naringenin chalcone affects HT-29 human colonic cells at 50 µM, showing activity levels of 102.0 after 6 hours and 94.1 after 24 hours. The compound is a potent inhibitor of Tau fibril formation (794.3 nM to 1412.5 nM) and general anesthesia (potency of 44,668.4 nM). It inhibits Menin-MLL interaction in leukemias (14,125.4 nM) and activates Cytochrome P450 3A4 (7943.3 nM). As a lipid storage modulator, it has a potency of 31,622.8 nM. Furthermore, Naringenin chalcone inhibits and activates N370S glucocerebrosidase (39,810.7 nM) for potential Gaucher Disease treatment and inhibits 15-hLO-2 (31,622.8 nM). It shows antifungal activity against multiple pathogens with varying MIC values: Candida albicans (>800,000.0 nM), Cryptococcus neoformans (400,000.0 nM), and Rhizopus stolonifer (>800,000.0 nM). In mice, Naringenin chalcone demonstrates antidepressant activity, reducing immobility time by 28.51% at 10 mg/kg. It acts as a positive allosteric modulator at human alpha7 nACHR (EC50 = 4000.0 nM). The compound also exhibits slight cytotoxicity against MCF7 and MDA-MB-231 cells (IC50 > 10,000.0 nM). Additionally, it inhibits alpha-glucosidase (IC50 = 71,100.0 nM) and shows antiallergic and anti-inflammatory activities in various mouse models..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Naringenin chalcone is a natural product isolated from the stem of the plant Machaerium isadelphum (Fabaceae).Naringenin chalcone has anti-inflammatory activity.
别名	柚皮素查耳酮, Isosalipurpol, Chalcononaringenin, Chalconaringenin, 2',4,4',6'-TETRAHYDROXYCHALCONE

化学信息

分子量	272.25
分子式	C₁₅H₁₂O₅
CAS No.	25515-46-2
Smiles	C(/C=C/C1=CC=C(O)C=C1)(=O)C2=C(O)C=C(O)C=C2O
密度	1.483 g/cm3 (Predicted)

储存&溶解度

存储

溶解度信息

DMSO: 50 mg/mL (183.65 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6731 mL	18.3655 mL	36.7309 mL	183.6547 mL
5 mM	0.7346 mL	3.6731 mL	7.3462 mL	36.7309 mL
10 mM	0.3673 mL	1.8365 mL	3.6731 mL	18.3655 mL
20 mM	0.1837 mL	0.9183 mL	1.8365 mL	9.1827 mL
50 mM	0.0735 mL	0.3673 mL	0.7346 mL	3.6731 mL
100 mM	0.0367 mL	0.1837 mL	0.3673 mL	1.8365 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

Naringenin chalcone

Naringenin chalcone

Naringenin chalcone