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Anti-HIF 2 alpha Polyclonal Antibody

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货号 TMAB-07023

Anti-HIF 2 alpha Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HIF 2 alpha。Anti-HIF 2 alpha Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-HIF 2 alpha Polyclonal Antibody

Anti-HIF 2 alpha Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-07023

Anti-HIF 2 alpha Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HIF 2 alpha。Anti-HIF 2 alpha Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-HIF 2 alpha Polyclonal Antibody is a Rabbit antibody targeting HIF 2 alpha. Anti-HIF 2 alpha Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Pig)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:400-800; IHC-Fr: 1:400-800; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus (Potential).
组织特异性Expressed in most tissues, with highest levels in lung, followed by heart, kidney, brain and liver. Predominantly expressed in endothelial cells. Also found in smooth muscle cells of the uterus, neurons, and brown adipose tissue. High expression in embryonic choroid plexus and kidney glomeruli.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
抗原信息
免疫原
KLH conjugated synthetic peptide: human HIF 2 alpha
抗原种属
Human
基因名称
EPAS1
基因ID
2034
蛋白名称
Endothelial PAS domain-containing protein 1
Uniprot ID
Q99814
功能
Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.
化学信息
分子量Theoretical: 96 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器
  • 配液 计算器
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