Anti-HIF-2 alpha Polyclonal Antibody is a Rabbit antibody targeting HIF-2 alpha. Anti-HIF-2 alpha Polyclonal Antibody can be used in FCM,ICC/IF,WB.

IgG

Mouse,Rat (predicted:Human)

25 μg total protein per Lane of various lysates probed with HIF 2 alpha polyclonal antibody, unconjugated (TMAB-00859) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.

WB: 1:500-2000; ICC/IF: 1:50-200; FCM: 1:20-100

Polyclonal

KLH conjugated synthetic peptide: mouse HIF 2 Alpha

Mouse

EPAS1

Endothelial PAS domain-containing protein 1

Response to hypoxia,HIF,HIF,HIF,HLH,Mitochondrial transcription,Hypoxia

Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.