Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Linvencorvir 是一种乙型肝炎病毒(HBV)核心蛋白变构调节剂,用于治疗慢性HBV 感染。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 993 | 现货 | ||
2 mg | ¥ 1,490 | 现货 | ||
5 mg | ¥ 2,650 | 现货 | ||
10 mg | ¥ 3,790 | 现货 | ||
25 mg | ¥ 6,130 | 现货 | ||
50 mg | ¥ 8,190 | 现货 | ||
100 mg | ¥ 10,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,490 | 现货 |
产品描述 | Linvencorvir is a hepatitis B virus (HBV) core protein variant modifier used to treat chronic HBV infection. |
体内活性 | Linvencorvir (RO7049389) (600/1000 mg; oral; Caucasian and Asian, male and female) followed by 100 μg intravenous [13 C]RO7049389. The model performance in predicting the pharmacokinetic profiles of RO7049389 aligned with clinical observations in Caucasians and was also successfully applied to Asians. Accordingly, the drug disposition pathways for RO7049389 were postulated with newly characterized estimates of the fractions: biliary excretion by P-glycoprotein (~41%), direct glucuronidation via uridine 5'-diphosphoglucuronosyltransferase 1A3 (~11%), hexose conjugation (~6%), oxidation by CYP3A4 (~28%) and other oxidation reactions (~9%). These results support the ongoing clinical development program for RO7049389 and highlight the broader value of PBPK and MB analyses in drug development.[3] |
别名 | RG7907 |
分子量 | 598.69 |
分子式 | C29H35FN6O5S |
CAS No. | 1808248-05-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 56.2 mg/mL (94.0 mM), Sonication and heating to 60℃ are recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6703 mL | 8.3516 mL | 16.7031 mL | 41.7578 mL |
5 mM | 0.3341 mL | 1.6703 mL | 3.3406 mL | 8.3516 mL | |
10 mM | 0.167 mL | 0.8352 mL | 1.6703 mL | 4.1758 mL | |
20 mM | 0.0835 mL | 0.4176 mL | 0.8352 mL | 2.0879 mL | |
50 mM | 0.0334 mL | 0.167 mL | 0.3341 mL | 0.8352 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Linvencorvir 1808248-05-6 Microbiology/Virology HBV Antibiotic RG7907 RG-7907 RG 7907 Inhibitor inhibitor inhibit